1-(2-(3,5-difluoro-2-hydroxyphenyl)-4-methyl-6-(3-phenoxyphenyl)pyrimidin-5-yl)ethanone

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Chemical Name:1-(2-(3,5-difluoro-2-hydroxyphenyl)-4-methyl-6-(3-phenoxyphenyl)pyrimidin-5-yl)ethanone
CAS No.:1565837-14-0
Molecular Formula:C₂₅H₁₈F₂N₂O₃
Molecular Weight:432.426
Hs Code.:

Synonyms:1-(2-(3,5-difluoro-2-hydroxyphenyl)-4-methyl-6-(3-phenoxyphenyl)pyrimidin-5-yl)ethanone

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Chemical Property of 1-(2-(3,5-difluoro-2-hydroxyphenyl)-4-methyl-6-(3-phenoxyphenyl)pyrimidin-5-yl)ethanone

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Technology Process of 1-(2-(3,5-difluoro-2-hydroxyphenyl)-4-methyl-6-(3-phenoxyphenyl)pyrimidin-5-yl)ethanone

There total 5 articles about 1-(2-(3,5-difluoro-2-hydroxyphenyl)-4-methyl-6-(3-phenoxyphenyl)pyrimidin-5-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1150114-51-4
(3,5-difluoro-2-hydroxyphenyl)boronic acid

: 1565836-98-7
C₁₉H₁₅ClN₂O₂

: 1565837-14-0
1-(2-(3,5-difluoro-2-hydroxyphenyl)-4-methyl-6-(3-phenoxyphenyl)pyrimidin-5-yl)ethanone

Guidance literature:: (3,5-difluoro-2-hydroxyphenyl)boronic acid; C₁₉H₁₅ClN₂O₂; In 1,4-dioxane; at 20 ℃; for 0.0833333h; Inert atmosphere;

With palladium diacetate; sodium carbonate; triphenylphosphine; In 1,4-dioxane; at 20 - 110 ℃; for 3.5h; Inert atmosphere;
DOI:10.1016/j.tetlet.2014.01.042

Reference yield:

: 1565836-95-4
C₁₉H₁₆N₂O₃

: 1565837-14-0
1-(2-(3,5-difluoro-2-hydroxyphenyl)-4-methyl-6-(3-phenoxyphenyl)pyrimidin-5-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-aniline; trichlorophosphate / 12 h / Reflux

2.1: 1,4-dioxane / 0.08 h / 20 °C / Inert atmosphere

2.2: 3.5 h / 20 - 110 °C / Inert atmosphere

With N,N-dimethyl-aniline; trichlorophosphate; In 1,4-dioxane; 2.1: |Suzuki-Miyaura Coupling / 2.2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.tetlet.2014.01.042

Reference yield:

: 39515-51-0
3-Phenoxybenzaldehyde

: 1565837-14-0
1-(2-(3,5-difluoro-2-hydroxyphenyl)-4-methyl-6-(3-phenoxyphenyl)pyrimidin-5-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water; ethanol / 3 h / Reflux

2.1: nitric acid / water / 0 - 20 °C

3.1: N,N-dimethyl-aniline; trichlorophosphate / 12 h / Reflux

4.1: 1,4-dioxane / 0.08 h / 20 °C / Inert atmosphere

4.2: 3.5 h / 20 - 110 °C / Inert atmosphere

With hydrogenchloride; nitric acid; N,N-dimethyl-aniline; trichlorophosphate; In 1,4-dioxane; ethanol; water; 1.1: |Biginelli Pyrimidone Synthesis / 4.1: |Suzuki-Miyaura Coupling / 4.2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.tetlet.2014.01.042