imidazo[1,2-a]pyridine-6-carboxylic acid (5-benzenesulfonyl-pyrimidin-2-ylmethyl)-amide

Base Information

Chemical Name:imidazo[1,2-a]pyridine-6-carboxylic acid (5-benzenesulfonyl-pyrimidin-2-ylmethyl)-amide
CAS No.:1454250-76-0
Molecular Formula:C₁₉H₁₅N₅O₃S
Molecular Weight:393.426
Hs Code.:

Synonyms:imidazo[1,2-a]pyridine-6-carboxylic acid (5-benzenesulfonyl-pyrimidin-2-ylmethyl)-amide

Suppliers and Price of imidazo[1,2-a]pyridine-6-carboxylic acid (5-benzenesulfonyl-pyrimidin-2-ylmethyl)-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of imidazo[1,2-a]pyridine-6-carboxylic acid (5-benzenesulfonyl-pyrimidin-2-ylmethyl)-amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of imidazo[1,2-a]pyridine-6-carboxylic acid (5-benzenesulfonyl-pyrimidin-2-ylmethyl)-amide

There total 6 articles about imidazo[1,2-a]pyridine-6-carboxylic acid (5-benzenesulfonyl-pyrimidin-2-ylmethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1454252-65-3
[5-(benzenesulfonyl)pyrimidin-2-yl]methanamine

: 139022-25-6
imidazo[1,2-a]pyridine-6-carboxylic acid

: 1454250-76-0
imidazo[1,2-a]pyridine-6-carboxylic acid (5-benzenesulfonyl-pyrimidin-2-ylmethyl)-amide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 38275-57-9
5-bromopyrimidine-2-carbonitrile

: 1454250-76-0
imidazo[1,2-a]pyridine-6-carboxylic acid (5-benzenesulfonyl-pyrimidin-2-ylmethyl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 100 °C

2: ammonium hydroxide; hydrogen / methanol; water / 4 h / 20 °C / 760.05 Torr

3: triethylamine / dichloromethane / 2.25 h / 20 °C

4: 3-chloro-benzenecarboperoxoic acid / chloroform / 1 h / 20 °C

5: hydrogenchloride / dichloromethane / 2 h / 20 °C

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; ammonium hydroxide; hydrogen; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;

Reference yield:

: 1454252-61-9
5-(phenylsulfanyl)pyrimidin-2-carbonitrile

: 1454250-76-0
imidazo[1,2-a]pyridine-6-carboxylic acid (5-benzenesulfonyl-pyrimidin-2-ylmethyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium hydroxide; hydrogen / methanol; water / 4 h / 20 °C / 760.05 Torr

2: triethylamine / dichloromethane / 2.25 h / 20 °C

3: 3-chloro-benzenecarboperoxoic acid / chloroform / 1 h / 20 °C

4: hydrogenchloride / dichloromethane / 2 h / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; ammonium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;