(2S,6RS)-7-ethoxy-2-[(2R)-3-(4-methoxybenzyloxy)-2-methylpropyl]-3,6-dihydro-2H-pyran

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Chemical Name:(2S,6RS)-7-ethoxy-2-[(2R)-3-(4-methoxybenzyloxy)-2-methylpropyl]-3,6-dihydro-2H-pyran
CAS No.:259199-00-3
Molecular Formula:C₁₉H₂₈O₄
Molecular Weight:320.429
Hs Code.:

Synonyms:(2S,6RS)-7-ethoxy-2-[(2R)-3-(4-methoxybenzyloxy)-2-methylpropyl]-3,6-dihydro-2H-pyran

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Chemical Property of (2S,6RS)-7-ethoxy-2-[(2R)-3-(4-methoxybenzyloxy)-2-methylpropyl]-3,6-dihydro-2H-pyran

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Technology Process of (2S,6RS)-7-ethoxy-2-[(2R)-3-(4-methoxybenzyloxy)-2-methylpropyl]-3,6-dihydro-2H-pyran

There total 6 articles about (2S,6RS)-7-ethoxy-2-[(2R)-3-(4-methoxybenzyloxy)-2-methylpropyl]-3,6-dihydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 259198-99-7
(4S,6R)-4-(1-ethoxyallyloxy)-7-(p-methoxybenzyloxy)-6-methylhept-1-ene

: 259199-00-3
(2S,6RS)-7-ethoxy-2-[(2R)-3-(4-methoxybenzyloxy)-2-methylpropyl]-3,6-dihydro-2H-pyran

Guidance literature:: With Grubbs catalyst first generation; In dichloromethane; Heating;
DOI:10.1016/S0040-4039(99)02021-3

Reference yield:

: 136320-64-4
(2R)-3-[(4-methoxybenzyl)oxy]-2-methylpropanol

: 259199-00-3
(2S,6RS)-7-ethoxy-2-[(2R)-3-(4-methoxybenzyloxy)-2-methylpropyl]-3,6-dihydro-2H-pyran

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / ethyl acetate / 16 h / 20 °C

2.1: 11.95 g / dimethylsulfoxide / 20 h / 80 °C

3.1: 80 percent / DIBALH / tetrahydrofuran; hexane / -78 - 20 °C

4.1: (-)-methoxydiisopinocampheylborane / diethyl ether / 3 h / 20 °C

4.2: diethyl ether; pentane / 1 h / -100 °C

4.3: 93 percent / NaBO₃*4H₂O / tetrahydrofuran; H₂O / 2 h / 20 °C

5.1: 84 percent / PPTS / toluene / 2 h / 40 °C / 60004.8 Torr

6.1: 94 percent / Cl₂(PCy₃)2Ru=CHPh / CH₂Cl₂ / 1 h / 40 °C

With pyridine; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; (-)-B-methoxydiisopinocampheylborane; Grubbs catalyst first generation; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1021/jo026743f

Reference yield:

: 259198-98-6
(4S,6R)-7-(p-methoxybenzyloxy)-6-methylhept-1-en-4-ol

: 259199-00-3
(2S,6RS)-7-ethoxy-2-[(2R)-3-(4-methoxybenzyloxy)-2-methylpropyl]-3,6-dihydro-2H-pyran

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / PPTS / toluene / 2 h / 40 °C / 60004.8 Torr

2: 94 percent / Cl₂(PCy₃)2Ru=CHPh / CH₂Cl₂ / 1 h / 40 °C

With pyridinium p-toluenesulfonate; Grubbs catalyst first generation; In dichloromethane; toluene;
DOI:10.1021/jo026743f