4-Isopropoxybenzenesulfonyl chloride

Base Information

• Chemical Name: 4-Isopropoxybenzenesulfonyl chloride
• CAS No.: 98995-40-5
• Molecular Formula: C9H11ClO3S
• Molecular Weight: 234.704
• Hs Code.: 29162090
• Mol file: 98995-40-5.mol

Synonyms:Benzenesulfonylchloride, p-isopropoxy- (6CI);

Chemical Property of 4-Isopropoxybenzenesulfonyl chloride

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 30-35 °C
• Refractive Index: 1.522
• Boiling Point: 333.666 °C at 760 mmHg
• Flash Point: 155.596 °C
• PSA: 51.75000
• Density: 1.279 g/cm³
• LogP: 3.48210
• Storage Temp.: 0-10°C
• Sensitive.: Moisture Sensitive
• Solubility.: soluble in Toluene

Purity/Quality:

99% ^*data from raw suppliers

4-Isopropoxybenzenesulfonyl Chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R34:Causes burns.
• Hazard Codes: R34:Causes burns.
• Statements: 34
• Safety Statements: 26-36/37/39-27

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Isopropoxybenzenesulfonyl chloride

There total 3 articles about 4-Isopropoxybenzenesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.62%

sodium 4-isopropoxybenzenesulfonate → 4-isopropoxybenzene-1-sulfonyl chloride (98995-40-5)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; for 4h; Reflux;

DOI:10.1016/j.bmc.2013.08.041

Reference yield:

sodium p-hydroxybenzenesulfonate (825-90-1) → 4-isopropoxybenzene-1-sulfonyl chloride (98995-40-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / methanol / 48 h / 80 °C

2: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 4 h / Reflux

With thionyl chloride; N,N-dimethyl-formamide; sodium hydroxide; In methanol; dichloromethane;

DOI:10.1016/j.bmc.2013.08.041

Reference yield:

→ 4-isopropoxybenzene-1-sulfonyl chloride (98995-40-5)

Guidance literature:

With phosphorus pentachloride;

DOI:10.1002/hlca.19560390616

upstream raw materials:

sodium p-hydroxybenzenesulfonate

Downstream raw materials:

4-isopropoxybenzenesulfonamide

1-{1-[(4-isopropoxyphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}-N-methylmethanamine

C₂₇H₄₂N₂O₃S

N-benzyl-N-(4-(diethylamino)benzyl)-4-isopropoxybenzenesulfonamide

Refernces