Technology Process of 4-[(2,3-dihydro-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol
There total 5 articles about 4-[(2,3-dihydro-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1-(Trimethylsilyl)imidazole;
In
1,2-dimethoxyethane;
at 80 ℃;
for 52h;
Inert atmosphere;
pressure tube;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / toluene; 1,2-dimethoxyethane; water / 16 h / 100 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C / Inert atmosphere
2.2: 72 h / 0 - 20 °C
3.1: 1-(Trimethylsilyl)imidazole / 1,2-dimethoxyethane / 52 h / 80 °C / Inert atmosphere; pressure tube
With
sodium hydride; potassium carbonate; 1-(Trimethylsilyl)imidazole;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,2-dimethoxyethane; water; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
2.1: hydrogen / palladium 10% on activated carbon / ethanol / 0.25 h / 1810.07 Torr
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C / Inert atmosphere
3.2: 72 h / 0 - 20 °C
4.1: 1-(Trimethylsilyl)imidazole / 1,2-dimethoxyethane / 52 h / 80 °C / Inert atmosphere; pressure tube
With
hydrogen; sodium hydride; triethylamine; 1-(Trimethylsilyl)imidazole;
palladium 10% on activated carbon;
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; mineral oil;