4-[(2,3-dihydro-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol

Base Information

Chemical Name:4-[(2,3-dihydro-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol
CAS No.:1264924-35-7
Molecular Formula:C₁₉H₁₈N₄O
Molecular Weight:318.378
Hs Code.:

Synonyms:4-[(2,3-dihydro-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol

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Chemical Property of 4-[(2,3-dihydro-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol

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Technology Process of 4-[(2,3-dihydro-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol

There total 5 articles about 4-[(2,3-dihydro-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1264924-32-4
1,1-dimethylethyl 1,3-dihydro-5-[[5-methoxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-2H-isoindole-2-carboxylate

: 1264924-35-7
4-[(2,3-dihydro-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol

Guidance literature:: With 1-(Trimethylsilyl)imidazole; In 1,2-dimethoxyethane; at 80 ℃; for 52h; Inert atmosphere; pressure tube;

Reference yield:

: 5720-05-8
4-methylphenylboronic acid

: 1264924-35-7
4-[(2,3-dihydro-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; 1,2-dimethoxyethane; water / 16 h / 100 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C / Inert atmosphere

2.2: 72 h / 0 - 20 °C

3.1: 1-(Trimethylsilyl)imidazole / 1,2-dimethoxyethane / 52 h / 80 °C / Inert atmosphere; pressure tube

With sodium hydride; potassium carbonate; 1-(Trimethylsilyl)imidazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; toluene; mineral oil;

Reference yield:

: 46053-72-9
5-nitroisoindoline

: 1264924-35-7
4-[(2,3-dihydro-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 0.25 h / 1810.07 Torr

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C / Inert atmosphere

3.2: 72 h / 0 - 20 °C

4.1: 1-(Trimethylsilyl)imidazole / 1,2-dimethoxyethane / 52 h / 80 °C / Inert atmosphere; pressure tube

With hydrogen; sodium hydride; triethylamine; 1-(Trimethylsilyl)imidazole; palladium 10% on activated carbon; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; mineral oil;