1,1-dimethylethyl 1,3-dihydro-5-[[5-methoxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-2H-isoindole-2-carboxylate

Base Information

Chemical Name:1,1-dimethylethyl 1,3-dihydro-5-[[5-methoxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-2H-isoindole-2-carboxylate
CAS No.:1264924-32-4
Molecular Formula:C₂₅H₂₈N₄O₃
Molecular Weight:432.522
Hs Code.:

Synonyms:1,1-dimethylethyl 1,3-dihydro-5-[[5-methoxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-2H-isoindole-2-carboxylate

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Chemical Property of 1,1-dimethylethyl 1,3-dihydro-5-[[5-methoxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-2H-isoindole-2-carboxylate

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Technology Process of 1,1-dimethylethyl 1,3-dihydro-5-[[5-methoxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-2H-isoindole-2-carboxylate

There total 6 articles about 1,1-dimethylethyl 1,3-dihydro-5-[[5-methoxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-2H-isoindole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1264926-40-0
C₁₂H₁₁ClN₂O

: 264916-06-5
tert‐butyl 5‐amino‐2,3‐dihydro‐1H‐isoindole‐2‐carboxylate

: 1264924-32-4
1,1-dimethylethyl 1,3-dihydro-5-[[5-methoxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-2H-isoindole-2-carboxylate

Guidance literature:: tert‐butyl 5‐amino‐2,3‐dihydro‐1H‐isoindole‐2‐carboxylate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.166667h; Inert atmosphere;

C₁₂H₁₁ClN₂O; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 72h;

With water; In tetrahydrofuran; mineral oil;

Reference yield:

: 5720-05-8
4-methylphenylboronic acid

: 1264924-32-4
1,1-dimethylethyl 1,3-dihydro-5-[[5-methoxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-2H-isoindole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; 1,2-dimethoxyethane; water / 16 h / 100 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C / Inert atmosphere

2.2: 72 h / 0 - 20 °C

With sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; toluene; mineral oil;

Reference yield:

: 46053-72-9
5-nitroisoindoline

: 1264924-32-4
1,1-dimethylethyl 1,3-dihydro-5-[[5-methoxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-2H-isoindole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 0.25 h / 1810.07 Torr

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C / Inert atmosphere

3.2: 72 h / 0 - 20 °C

With hydrogen; sodium hydride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; mineral oil;