Technology Process of N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid benzyl ester
There total 16 articles about N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid benzyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 92 percent / NEt3 / tetrahydrofuran; H2O / 2 h / Ambient temperature
2: 41 percent / PPh3, diisopropyl azodicarboxylate / tetrahydrofuran / 1.5 h / Ambient temperature
3: 81.7 percent / dioxane; H2O / 50 °C
4: 1.) Et3N / 1.) MeCN, room temperature, 1h, 2.) 2-3 h room temperature
With
di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine;
In
tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/jo00149a005
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 78 percent / PPh3, DEAD / tetrahydrofuran / 1.5 h / Ambient temperature
2: 65 percent / H2 / 5percent Pd/C / ethyl acetate / 3 h / 0 °C / 760 Torr
3: 97 percent / HCl gas / diethyl ether / 0 °C
4: Et3N / acetonitrile / 3.5 h / Ambient temperature
5: 75 percent / dioxane; H2O / 168 h
6: 1.) Et3N / 1.) MeCN, room temperature, 1h, 2.) 2-3 h room temperature
With
hydrogenchloride; hydrogen; triethylamine; triphenylphosphine; diethylazodicarboxylate;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; water; ethyl acetate; acetonitrile;
DOI:10.1021/jo00149a005
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 89 percent / PPh3, DEAD / tetrahydrofuran / 1.5 h / Ambient temperature
2: 55 percent / H2 / 5percent Pd/C / ethyl acetate / 3 h / 0 °C / 760 Torr
3: 97 percent / HCl gas / diethyl ether / 0 °C
4: Et3N / acetonitrile / 3.5 h / Ambient temperature
5: 75 percent / dioxane; H2O / 168 h
6: 1.) Et3N / 1.) MeCN, room temperature, 1h, 2.) 2-3 h room temperature
With
hydrogenchloride; hydrogen; triethylamine; triphenylphosphine; diethylazodicarboxylate;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; water; ethyl acetate; acetonitrile;
DOI:10.1021/jo00149a005
