Technology Process of (6S,10S)-benzyl 9-cyano-5-methyl-6,7,10,11-tetrahydro-6,10-imino-5H-cyclooctindole-12-carboxylate
There total 8 articles about (6S,10S)-benzyl 9-cyano-5-methyl-6,7,10,11-tetrahydro-6,10-imino-5H-cyclooctindole-12-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
(1,4,7,10-tetraoxacyclododecane);
tetrakis(triphenylphosphine) palladium(0);
In
benzene;
for 3h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 62 percent / NaHCO3 / CH2Cl2 / 4 h / Ambient temperature
2: 82 percent / NaH / dimethylformamide / 1) 0 deg C, 1 h, 2) RT, 30 min
3: 70 percent / NaH, MeOH / dimethylformamide / 5 h / Ambient temperature
4: 73 percent / NaCl / H2O; dimethylformamide / 6 h / 130 °C
5: 53 percent / NaH / tetrahydrofuran / 2 h / Ambient temperature
6: 52 percent / 12-crown-4 / Pd(PPh3)4 / benzene / 3 h / Ambient temperature
With
methanol; (1,4,7,10-tetraoxacyclododecane); sodium hydride; sodium hydrogencarbonate; sodium chloride;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; benzene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: TFA / CH2Cl2 / 2 h / 0 °C
2: 62 percent / NaHCO3 / CH2Cl2 / 4 h / Ambient temperature
3: 82 percent / NaH / dimethylformamide / 1) 0 deg C, 1 h, 2) RT, 30 min
4: 70 percent / NaH, MeOH / dimethylformamide / 5 h / Ambient temperature
5: 73 percent / NaCl / H2O; dimethylformamide / 6 h / 130 °C
6: 53 percent / NaH / tetrahydrofuran / 2 h / Ambient temperature
7: 52 percent / 12-crown-4 / Pd(PPh3)4 / benzene / 3 h / Ambient temperature
With
methanol; (1,4,7,10-tetraoxacyclododecane); sodium hydride; sodium hydrogencarbonate; trifluoroacetic acid; sodium chloride;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; benzene;
