6-[6-(2,6-Dichlorophenyl)-8-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-hexanoic acid, tert-butyl ester

Base Information

Chemical Name:6-[6-(2,6-Dichlorophenyl)-8-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-hexanoic acid, tert-butyl ester
CAS No.:185039-70-7
Molecular Formula:C₂₄H₂₈Cl₂N₄O₃
Molecular Weight:491.417
Hs Code.:

Synonyms:6-[6-(2,6-Dichlorophenyl)-8-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-hexanoic acid, tert-butyl ester

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Chemical Property of 6-[6-(2,6-Dichlorophenyl)-8-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-hexanoic acid, tert-butyl ester

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Technology Process of 6-[6-(2,6-Dichlorophenyl)-8-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-hexanoic acid, tert-butyl ester

There total 9 articles about 6-[6-(2,6-Dichlorophenyl)-8-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-hexanoic acid, tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 5514-98-7
6-aminohexanoic acid tert-butyl ester

: 185039-48-9
6-(2,6-dichlorophenyl)-8-methyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one

: 185039-70-7
6-[6-(2,6-Dichlorophenyl)-8-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-hexanoic acid, tert-butyl ester

Guidance literature:: at 120 ℃; for 0.166667h;
DOI:10.1021/jm9802259

Reference yield:

: 17759-30-7
(4-methylamino-2-methylsulfanyl-pyrimidin-5-yl)-methanol

: 185039-70-7
6-[6-(2,6-Dichlorophenyl)-8-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-hexanoic acid, tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / MnO₂ / CHCl₃ / 6 h / Ambient temperature

2: 46 percent / K₂CO₃ / dimethylformamide / 18 h / 100 - 105 °C

3: 88 percent / 0.08 h / Heating

4: 96 percent / 6N aq. HCl / Heating

5: 92 percent / m-CPBA / CHCl₃ / 25 °C

6: 77 percent / 0.17 h / 120 °C

With hydrogenchloride; manganese(IV) oxide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm9802259

Reference yield:

: 5909-24-0
4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester

: 185039-70-7
6-[6-(2,6-Dichlorophenyl)-8-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-hexanoic acid, tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 81 percent / Et₃N / tetrahydrofuran; H₂O / 0.5 h / 25 °C

2: 84 percent / LiAlH₄ / tetrahydrofuran / 0.17 h / Ambient temperature

3: 93 percent / MnO₂ / CHCl₃ / 6 h / Ambient temperature

4: 46 percent / K₂CO₃ / dimethylformamide / 18 h / 100 - 105 °C

5: 88 percent / 0.08 h / Heating

6: 96 percent / 6N aq. HCl / Heating

7: 92 percent / m-CPBA / CHCl₃ / 25 °C

8: 77 percent / 0.17 h / 120 °C

With hydrogenchloride; manganese(IV) oxide; lithium aluminium tetrahydride; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm9802259