(2S,3R)-3-(2-Methyl-allyl)-4-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

Base Information

Chemical Name:(2S,3R)-3-(2-Methyl-allyl)-4-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester
CAS No.:394735-51-4
Molecular Formula:C₁₇H₁₉NO₅
Molecular Weight:317.342
Hs Code.:

Synonyms:(2S,3R)-3-(2-Methyl-allyl)-4-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

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Chemical Property of (2S,3R)-3-(2-Methyl-allyl)-4-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

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Technology Process of (2S,3R)-3-(2-Methyl-allyl)-4-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

There total 2 articles about (2S,3R)-3-(2-Methyl-allyl)-4-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 394735-50-3
C₁₈H₂₁NO₅

: 394735-51-4
(2S,3R)-3-(2-Methyl-allyl)-4-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

Guidance literature:: C₁₈H₂₁NO₅; With lithium hydroxide; water; In 1,4-dioxane; at 20 ℃; for 20h;

With hydrogenchloride; In water; at 0 ℃; pH=1.65;

Reference yield:

: 16217-15-5
1-benzyloxycarbonyl-4-oxo-L-proline methyl ester

: 394735-51-4
(2S,3R)-3-(2-Methyl-allyl)-4-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: molecular sieve 4 Angstroem / toluene / 20 °C

2: 2.43 g / NaI; K₂CO₃ / acetonitrile / 24 h / 20 °C

3: 1.72 g / aq. LiOH / dioxane / 20 h

With lithium hydroxide; 4 A molecular sieve; potassium carbonate; sodium iodide; In 1,4-dioxane; toluene; acetonitrile;
DOI:10.1016/j.tetlet.2004.06.070

Reference yield: 98.0%

: 394735-51-4
(2S,3R)-3-(2-Methyl-allyl)-4-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

: 394735-52-5
(2S,3R,4R)-4-Hydroxy-3-(2-methyl-allyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

Guidance literature:: (2S,3R)-3-(2-Methyl-allyl)-4-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester; With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; for 0.666667h;

In acetic acid; at 20 ℃; for 20h; Further stages.;
DOI:10.1016/j.tetlet.2004.06.070