(2S,3R,4R)-4-Hydroxy-3-(2-methyl-allyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

Base Information

Chemical Name:(2S,3R,4R)-4-Hydroxy-3-(2-methyl-allyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester
CAS No.:394735-52-5
Molecular Formula:C₁₇H₂₁NO₅
Molecular Weight:319.357
Hs Code.:

Synonyms:(2S,3R,4R)-4-Hydroxy-3-(2-methyl-allyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

Suppliers and Price of (2S,3R,4R)-4-Hydroxy-3-(2-methyl-allyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R,4R)-4-Hydroxy-3-(2-methyl-allyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R,4R)-4-Hydroxy-3-(2-methyl-allyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

There total 3 articles about (2S,3R,4R)-4-Hydroxy-3-(2-methyl-allyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 394735-51-4
(2S,3R)-3-(2-Methyl-allyl)-4-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

: 394735-52-5
(2S,3R,4R)-4-Hydroxy-3-(2-methyl-allyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

Guidance literature:: (2S,3R)-3-(2-Methyl-allyl)-4-oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester; With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; for 0.666667h;

In acetic acid; at 20 ℃; for 20h; Further stages.;
DOI:10.1016/j.tetlet.2004.06.070

Reference yield:

: 16217-15-5
1-benzyloxycarbonyl-4-oxo-L-proline methyl ester

: 394735-52-5
(2S,3R,4R)-4-Hydroxy-3-(2-methyl-allyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: molecular sieve 4 Angstroem / toluene / 20 °C

2.1: 2.43 g / NaI; K₂CO₃ / acetonitrile / 24 h / 20 °C

3.1: 1.72 g / aq. LiOH / dioxane / 20 h

4.1: NaBH(OAc)3; AcOH / CH₂Cl₂ / 0.67 h

4.2: 98 percent / acetic acid / 20 h / 20 °C

With lithium hydroxide; 4 A molecular sieve; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; sodium iodide; In 1,4-dioxane; dichloromethane; toluene; acetonitrile;
DOI:10.1016/j.tetlet.2004.06.070

Reference yield:

: 757994-70-0
N-benzyloxycarbonyl-3-(2-methylallyl)-4-oxo-L-proline methyl ester

: 394735-52-5
(2S,3R,4R)-4-Hydroxy-3-(2-methyl-allyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1.72 g / aq. LiOH / dioxane / 20 h

2.1: NaBH(OAc)3; AcOH / CH₂Cl₂ / 0.67 h

2.2: 98 percent / acetic acid / 20 h / 20 °C

With lithium hydroxide; sodium tris(acetoxy)borohydride; acetic acid; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.tetlet.2004.06.070