(1R,9R,10R)-10-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-4-methyl-8,11-dioxa-2,6-diaza-tricyclo[7.2.1.0^2,7]dodeca-3,6-dien-5-one

Base Information

• Chemical Name: (1R,9R,10R)-10-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-4-methyl-8,11-dioxa-2,6-diaza-tricyclo[7.2.1.0^2,7]dodeca-3,6-dien-5-one
• CAS No.: 209255-47-0
• Molecular Formula: C₃₀H₂₉N₃O₄
• Molecular Weight: 495.578

Synonyms:(1R,9R,10R)-10-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-4-methyl-8,11-dioxa-2,6-diaza-tricyclo[7.2.1.0^2,7]dodeca-3,6-dien-5-one

Chemical Property of (1R,9R,10R)-10-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-4-methyl-8,11-dioxa-2,6-diaza-tricyclo[7.2.1.0^2,7]dodeca-3,6-dien-5-one

Chemical Property:

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Technology Process of (1R,9R,10R)-10-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-4-methyl-8,11-dioxa-2,6-diaza-tricyclo[7.2.1.0^2,7]dodeca-3,6-dien-5-one

There total 3 articles about (1R,9R,10R)-10-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-4-methyl-8,11-dioxa-2,6-diaza-tricyclo[7.2.1.0^2,7]dodeca-3,6-dien-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methanesulfonic acid (2R,3S,5R)-2-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester (278168-48-2) → (1R,9R,10R)-10-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-4-methyl-8,11-dioxa-2,6-diaza-tricyclo[7.2.1.02,7]dodeca-3,6-dien-5-one (209255-47-0)

Guidance literature:

With potassium phtalimide; In water; N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1016/S0960-894X(00)00085-8

Reference yield:

5'-amino-5'-deoxythymidine (25152-20-9) → (1R,9R,10R)-10-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-4-methyl-8,11-dioxa-2,6-diaza-tricyclo[7.2.1.02,7]dodeca-3,6-dien-5-one (209255-47-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / DMAP; pyridine

2: 88 percent / pyridine / 0 - 20 °C

3: potassium phthalimide / dimethylformamide; H₂O / 100 °C

With pyridine; dmap; potassium phtalimide; In water; N,N-dimethyl-formamide; 1: Alkylation / 2: mesylation / 3: Cyclization;

DOI:10.1016/S0960-894X(00)00085-8

Reference yield:

mono-4-methoxytrityl chloride (14470-28-1) → (1R,9R,10R)-10-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-4-methyl-8,11-dioxa-2,6-diaza-tricyclo[7.2.1.02,7]dodeca-3,6-dien-5-one (209255-47-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / DMAP; pyridine

2: 88 percent / pyridine / 0 - 20 °C

3: potassium phthalimide / dimethylformamide; H₂O / 100 °C

With pyridine; dmap; potassium phtalimide; In water; N,N-dimethyl-formamide; 1: Alkylation / 2: mesylation / 3: Cyclization;

DOI:10.1016/S0960-894X(00)00085-8

upstream raw materials:

Methanesulfonic acid (2R,3S,5R)-2-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

5'-amino-5'-deoxythymidine

mono-4-methoxytrityl chloride

Downstream raw materials:

[[(2R,3S,5R)-2-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-(2,2,2-trifluoro-acetyl)-amino]-acetic acid methyl ester

[(2R,3S,5R)-2-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-ylamino]-acetic acid methyl ester

1-[(2R,4S,5R)-4-Isothiocyanato-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

5'-monomethoxytritylamino-3'-amino-2',3',5'-trideoxythymidine

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