N-{1-[2-(1H-pyrrol-1-yl)phenyl]-2-(cyclohexylamino)-2-oxoethyl}-N-(benzo[d][1,3]dioxol-5-ylmethyl)but-2-ynamide

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Chemical Name:N-{1-[2-(1H-pyrrol-1-yl)phenyl]-2-(cyclohexylamino)-2-oxoethyl}-N-(benzo[d][1,3]dioxol-5-ylmethyl)but-2-ynamide
CAS No.:1604835-47-3
Molecular Formula:C₃₀H₃₁N₃O₄
Molecular Weight:497.594
Hs Code.:

Synonyms:N-{1-[2-(1H-pyrrol-1-yl)phenyl]-2-(cyclohexylamino)-2-oxoethyl}-N-(benzo[d][1,3]dioxol-5-ylmethyl)but-2-ynamide

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Chemical Property of N-{1-[2-(1H-pyrrol-1-yl)phenyl]-2-(cyclohexylamino)-2-oxoethyl}-N-(benzo[d][1,3]dioxol-5-ylmethyl)but-2-ynamide

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Technology Process of N-{1-[2-(1H-pyrrol-1-yl)phenyl]-2-(cyclohexylamino)-2-oxoethyl}-N-(benzo[d][1,3]dioxol-5-ylmethyl)but-2-ynamide

There total 3 articles about N-{1-[2-(1H-pyrrol-1-yl)phenyl]-2-(cyclohexylamino)-2-oxoethyl}-N-(benzo[d][1,3]dioxol-5-ylmethyl)but-2-ynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 2620-50-0
1,3-benzodioxol-5-ylmethyl amine

: 931-53-3
Cyclohexyl isocyanide

: 31739-56-7
2-(1H-pyrrol-1-yl)benzaldehyde

: 590-93-2
2-Butynoic acid

: 1604835-47-3
N-{1-[2-(1H-pyrrol-1-yl)phenyl]-2-(cyclohexylamino)-2-oxoethyl}-N-(benzo[d][1,3]dioxol-5-ylmethyl)but-2-ynamide

Guidance literature:: With sodium sulfate; In methanol; at 20 ℃; for 48h;
DOI:10.1002/ejoc.201301507

Reference yield:

: 10333-67-2
methyl 2-(1H-pyrrol-1-yl)benzoate

: 1604835-47-3
N-{1-[2-(1H-pyrrol-1-yl)phenyl]-2-(cyclohexylamino)-2-oxoethyl}-N-(benzo[d][1,3]dioxol-5-ylmethyl)but-2-ynamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 0 °C

2: silica gel; pyridinium chlorochromate / dichloromethane / 3 h / 20 °C

3: sodium sulfate / methanol / 48 h / 20 °C

With lithium aluminium tetrahydride; silica gel; sodium sulfate; pyridinium chlorochromate; In methanol; diethyl ether; dichloromethane; 3: |Ugi Condensation;
DOI:10.1002/ejoc.201301507

Reference yield:

: 61034-86-4
2-(pyrrol-1-yl)-benzyl alcohol

: 1604835-47-3
N-{1-[2-(1H-pyrrol-1-yl)phenyl]-2-(cyclohexylamino)-2-oxoethyl}-N-(benzo[d][1,3]dioxol-5-ylmethyl)but-2-ynamide

Guidance literature:: Multi-step reaction with 2 steps

1: silica gel; pyridinium chlorochromate / dichloromethane / 3 h / 20 °C

2: sodium sulfate / methanol / 48 h / 20 °C

With silica gel; sodium sulfate; pyridinium chlorochromate; In methanol; dichloromethane; 2: |Ugi Condensation;
DOI:10.1002/ejoc.201301507