5-amino-1,3-dibenzyl-6-phenethyl pyrimidine-2,4(1H,3H)-dione

Base Information

• Chemical Name: 5-amino-1,3-dibenzyl-6-phenethyl pyrimidine-2,4(1H,3H)-dione
• CAS No.: 950664-86-5
• Molecular Formula: C₂₆H₂₅N₃O₂
• Molecular Weight: 411.503
• Mol file: 950664-86-5.mol

Synonyms:5-amino-1,3-dibenzyl-6-phenethyl pyrimidine-2,4(1H,3H)-dione

Chemical Property of 5-amino-1,3-dibenzyl-6-phenethyl pyrimidine-2,4(1H,3H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-amino-1,3-dibenzyl-6-phenethyl pyrimidine-2,4(1H,3H)-dione

There total 2 articles about 5-amino-1,3-dibenzyl-6-phenethyl pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1,3-dibenzyl-5-nitro-6-phenethylpyrimidine-2,4(1H,3H)-dione (950664-85-4) → 5-amino-1,3-dibenzyl-6-phenethyl pyrimidine-2,4(1H,3H)-dione (950664-86-5)

Guidance literature:

With sodium dithionite; In methanol; for 0.5h; Heating;

DOI:10.1080/00397910701412737

Reference yield:

6-Methyluracil (626-48-2) → 5-amino-1,3-dibenzyl-6-phenethyl pyrimidine-2,4(1H,3H)-dione (950664-86-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / P₂O₅; fuming HNO₃ / cooling

2: 66 percent / NaH / dimethylformamide / 3 h / 20 °C

3: 89 percent / Na₂S₂O₄ / methanol / 0.5 h / Heating

With sodium dithionite; nitric acid; phosphorus pentoxide; sodium hydride; In methanol; N,N-dimethyl-formamide;

DOI:10.1080/00397910701412737

Reference yield: 40.0%

5-amino-1,3-dibenzyl-6-phenethyl pyrimidine-2,4(1H,3H)-dione (950664-86-5) + methyl iodide (74-88-4) → 1,3-dibenzyl-5-(N,N-dimethylamino)-6-phenethyluracil (950664-87-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1080/00397910701412737

upstream raw materials:

1,3-dibenzyl-5-nitro-6-phenethylpyrimidine-2,4(1H,3H)-dione

6-Methyluracil

Downstream raw materials:

1,3-dibenzyl-5-(N,N-dimethylamino)-6-phenethyluracil