<1S-(1α,2β,3α)>-3-(2-Amino-6-iodo-7H-purin-7-yl)-1,2-cyclobutanedimethanol dibenzoate ester

Base Information

• Chemical Name: <1S-(1α,2β,3α)>-3-(2-Amino-6-iodo-7H-purin-7-yl)-1,2-cyclobutanedimethanol dibenzoate ester
• CAS No.: 163928-96-9
• Molecular Formula: C₂₅H₂₂IN₅O₄
• Molecular Weight: 583.385
• Mol file: 163928-96-9.mol

Synonyms:<1S-(1α,2β,3α)>-3-(2-Amino-6-iodo-7H-purin-7-yl)-1,2-cyclobutanedimethanol dibenzoate ester

Chemical Property of <1S-(1α,2β,3α)>-3-(2-Amino-6-iodo-7H-purin-7-yl)-1,2-cyclobutanedimethanol dibenzoate ester

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of <1S-(1α,2β,3α)>-3-(2-Amino-6-iodo-7H-purin-7-yl)-1,2-cyclobutanedimethanol dibenzoate ester

There total 5 articles about <1S-(1α,2β,3α)>-3-(2-Amino-6-iodo-7H-purin-7-yl)-1,2-cyclobutanedimethanol dibenzoate ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-amino-6-iodopurine tetra-n-butylammonium salt + C21H19F3O7S (163928-93-6) → <1S-(1α,2β,3α)>-3-(2-Amino-6-iodo-7H-purin-7-yl)-1,2-cyclobutanedimethanol dibenzoate ester (163928-96-9) + <1S-(1α,2β,3α)>-3-(2-Amino-6-iodo-9H-purin-9-yl)-1,2-cyclobutanedimethanol dibenzoate ester (156126-83-9)

Guidance literature:

In dichloromethane; at 25 ℃; regioselective reaction;

DOI:10.1021/op970214+

Reference yield: 76.0%

C22H19F3O6 + 2-amino-6-iodopurine tetra-n-butylammonium salt → <1S-(1α,2β,3α)>-3-(2-Amino-6-iodo-7H-purin-7-yl)-1,2-cyclobutanedimethanol dibenzoate ester (163928-96-9) + <1S-(1α,2β,3α)>-3-(2-Amino-6-iodo-9H-purin-9-yl)-1,2-cyclobutanedimethanol dibenzoate ester (156126-83-9)

Guidance literature:

In dichloromethane; Yield given; 1.) ice bath temp., 30 min, 2.) room temp., overnight;

DOI:10.1021/jo00114a047

Reference yield: 70.0%

6-Iodo-9H-purin-2-amine ion(1-) triethyl(phenylmethyl)ammonium salt + C21H19F3O7S (163928-93-6) → <1S-(1α,2β,3α)>-3-(2-Amino-6-iodo-7H-purin-7-yl)-1,2-cyclobutanedimethanol dibenzoate ester (163928-96-9) + <1S-(1α,2β,3α)>-3-(2-Amino-6-iodo-9H-purin-9-yl)-1,2-cyclobutanedimethanol dibenzoate ester (156126-83-9)

Guidance literature:

In dichloromethane; at 25 ℃; regioselective reaction;

DOI:10.1021/op970214+

upstream raw materials:

C₂₁H₁₉F₃O₇S