156126-83-9Relevant academic research and scientific papers
Expedient approach to chiral cyclobutanones: Asymmetric synthesis of cyclobut-G
Darses, Benjamin,Greene, Andrew E.,Coote, Susannah C.,Poisson, Jean-Francois
scheme or table, p. 821 - 824 (2009/04/10)
An efficient one-pot asymmetric synthesis of cyclobutanones from chiral enol ethers is described. The approach is illustrated with alkyl- and functionalized alkyl-substituted enol ethers (nine examples). A new enantioselective synthesis of cyclobut-G (Lobucavir) could thus be achieved.
Process for preparing guanine-containing antiviral agents and purinyl salts useful in such process
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, (2008/06/13)
A purine salt of the formula STR1 wherein Y1 is chloro, bromo, or iodo, and R1, R2, R3, and R4 are independently selected from alkyl and substituted alkyl is reacted with the compound of the formula to yield the purine of the formula STR2 wherein x is a leaving group, and Z1 is a protected form of the carbohydrate surrogate Z. Several routes are disclosed for converting this intermediate to the antiviral agent STR3
A practical asymmetric synthesis of the antiviral agent lobucavir, BMS-180194
Singh, Janak,Bisacchi, Gregory S.,Ahmad, Saleem,Godfrey Jr., Jollie D.,Kissick, Thomas P.,Mitt, Toomas,Kocy, Octavian,Vu, Truc,Papaioannou, Chris G.,Wong, Michael K.,Heikes, James E.,Zahler, Robert,Mueller, Richard H.
, p. 393 - 399 (2013/09/08)
A practical synthesis of the antiviral agent lobucavir, [1R-(1α,2β,3α)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobutyl]- 6H-purin-6-one (BMS-180194), is described. The key chiral intermediate, [1S-(1α,2β,3α)]-3-hydroxy-1,2-cyclobutanedimethanol, dibenzoate e
