N-(2-(benzyloxy)-5-hydroxypyridin-4-yl)-4-(cyclopropylmethoxy)benzamide

Base Information

Chemical Name:N-(2-(benzyloxy)-5-hydroxypyridin-4-yl)-4-(cyclopropylmethoxy)benzamide
CAS No.:1431535-52-2
Molecular Formula:C₂₃H₂₂N₂O₄
Molecular Weight:390.439
Hs Code.:

Synonyms:N-(2-(benzyloxy)-5-hydroxypyridin-4-yl)-4-(cyclopropylmethoxy)benzamide

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Chemical Property of N-(2-(benzyloxy)-5-hydroxypyridin-4-yl)-4-(cyclopropylmethoxy)benzamide

Chemical Property:

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Technology Process of N-(2-(benzyloxy)-5-hydroxypyridin-4-yl)-4-(cyclopropylmethoxy)benzamide

There total 1 articles about N-(2-(benzyloxy)-5-hydroxypyridin-4-yl)-4-(cyclopropylmethoxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 355391-05-8
4-(cyclopropylmethoxy)benzoic acid

: 1431535-50-0
4-amino-6-(benzyloxy)pyridin-3-ol monohydrochloride

: 1431535-52-2
N-(2-(benzyloxy)-5-hydroxypyridin-4-yl)-4-(cyclopropylmethoxy)benzamide

Guidance literature:: 4-(cyclopropylmethoxy)benzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 1h;

4-amino-6-(benzyloxy)pyridin-3-ol monohydrochloride; With pyridine; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Cooling with ice;

With sodium hydride; In water; at 20 ℃; for 15h;

Reference yield:

: 1431535-52-2
N-(2-(benzyloxy)-5-hydroxypyridin-4-yl)-4-(cyclopropylmethoxy)benzamide

: 1431535-54-4
6-(benzyloxy)-2-(4-(cyclopropylmethoxy)phenyl) [1,3]oxazolo[5,4-c]pyridine

Guidance literature:: With triethylamine; In hexachloroethane; acetonitrile; at 20 ℃; for 15h;

Reference yield:

: 1431535-52-2
N-(2-(benzyloxy)-5-hydroxypyridin-4-yl)-4-(cyclopropylmethoxy)benzamide

: 1467081-09-9
tert-butyl ((2S)-1-((2-(4-(cyclopropylmethoxy)phenyl)[1,3]oxazolo[5,4-c]pyridin-6-yl)oxy)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / acetonitrile; hexachloroethane / 15 h / 20 °C

2.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; water / 15 h / 20 °C

2.2: 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; hexachloroethane; water; acetonitrile;