(S)-1-Cbz-3-Aminopyrrolidine

Base Information

Chemical Name:(S)-1-Cbz-3-Aminopyrrolidine
CAS No.:122536-72-5
Molecular Formula:C12H16N2O2
Molecular Weight:220.271
Hs Code.:29339900
European Community (EC) Number:693-371-9
DSSTox Substance ID:DTXSID40364012
Wikidata:Q72516002
Mol file:122536-72-5.mol

Synonyms:122536-72-5;(S)-1-Cbz-3-Aminopyrrolidine;(S)-(+)-1-Cbz-3-aminopyrrolidine;(S)-3-AMINO-1-CBZ-PYRROLIDINE;benzyl (3S)-3-aminopyrrolidine-1-carboxylate;(S)-3-Amino-pyrrolidine-1-carboxylic acid benzyl ester;MFCD06858462;1-Pyrrolidinecarboxylic acid, 3-amino-, phenylmethyl ester, (S)-;1-Pyrrolidinecarboxylic acid, 3-amino-, phenylmethyl ester, (3S)-;SCHEMBL1189968;(3S)-1-Cbz-3-aminopyrrolidine;DTXSID40364012;(3S)-1-Cbz-3-amino-pyrrolidine;AKOS005258644;AKOS015889707;AC-7176;AM91185;CS-W013140;AS-80278;TS-03148;(S)-(+)-1-Cbz-3-aminopyrrolidine, 97%;(S)-benzyl 3-aminopyrrolidine-1-carboxylate;A2580;P10427;J-004818;phenylmethyl (3S)-3-amino-1-pyrrolidinecarboxylate;(S)-3-AMINO-1-(BENZYLOXYCARBONYL)PYRROLIDINE;(S)-3-aminopyrrolidine-1-carboxylic acid benzyl ester;(3S)-3-amino-pyrrolidine-1-carboxylic acid, benzyl ester;(S)-(+)-3-AMINO-1-(BENZYLOXYCARBONYL)PYRROLIDINE;(S)-3-Amino-1-pyrrolidinecarboxylic acid, phenylmethyl ester

Suppliers and Price of (S)-1-Cbz-3-Aminopyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-3-Amino-1-Cbz-pyrrolidine
100mg
$ 105.00

TRC
(S)-3-Amino-1-Cbz-pyrrolidine
50mg
$ 70.00

Synthonix
(S)-3-Amino-1-Cbz-pyrrolidine 95+%
5g
$ 140.00

Synthonix
(S)-3-Amino-1-Cbz-pyrrolidine 95+%
1g
$ 50.00

Synthonix
(S)-3-Amino-1-Cbz-pyrrolidine 95+%
25g
$ 470.00

Synthonix
(S)-3-Amino-1-Cbz-pyrrolidine 95+%
50g
$ 830.00

Synthonix
(S)-3-Amino-1-Cbz-pyrrolidine 95+%
10g
$ 240.00

SynQuest Laboratories
Benzyl (3S)-3-aminopyrrolidine-1-carboxylate 97.0%
25 g
$ 890.00

SynQuest Laboratories
Benzyl (3S)-3-aminopyrrolidine-1-carboxylate 97.0%
5 g
$ 540.00

SynQuest Laboratories
Benzyl (3S)-3-aminopyrrolidine-1-carboxylate 97.0%
1 g
$ 190.00

Total 70 raw suppliers

Chemical Property of (S)-1-Cbz-3-Aminopyrrolidine

Chemical Property:

Vapor Pressure:4.04E-05mmHg at 25°C
Melting Point:310-316℃
Refractive Index:n20/D 1.548
Boiling Point:351.7 °C at 760 mmHg
PKA:9.52±0.20(Predicted)
Flash Point:166.5 °C
PSA：55.56000
Density:1.155 g/cm³
LogP:1.99440
Sensitive.:Air Sensitive
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:220.121177757
Heavy Atom Count:16
Complexity:239

Purity/Quality:

99% ^*data from raw suppliers

(S)-3-Amino-1-Cbz-pyrrolidine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CC1N)C(=O)OCC2=CC=CC=C2
Isomeric SMILES:C1CN(C[C@H]1N)C(=O)OCC2=CC=CC=C2

Technology Process of (S)-1-Cbz-3-Aminopyrrolidine

There total 5 articles about (S)-1-Cbz-3-Aminopyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 122536-74-7
(S)-3-<<(1,1-dimethylethoxy)carbonyl>amino>-1-pyrrolidinecarboxylic acid phenylmethyl ester

: 122536-72-5
(S)-3-amino-1-pyrrolidinecarboxylic acid phenylmethyl ester

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 2h;

Reference yield: 95.0%

: 122536-70-3
(S)-3-azido-1-pyrrolidinecarboxylic acid phenylmethyl ester

: 122536-72-5
(S)-3-amino-1-pyrrolidinecarboxylic acid phenylmethyl ester

Guidance literature:: With hydrogen; nickel; In methanol; at 21.5 - 25 ℃; for 21.5h; under 2585.7 Torr;
DOI:10.1021/jm00088a011

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 122536-72-5
(S)-3-amino-1-pyrrolidinecarboxylic acid phenylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / 10percent aq. NaOH / 2 h / 5 °C

2: 91 percent / pyridine / 2 h / 5 °C

3: 98 percent / sodium azide / dimethylformamide / 2 h / 100 °C

4: 95 percent / H₂ / Raney nickel / methanol / 21.5 h / 21.5 - 25 °C / 2585.7 Torr

With pyridine; sodium hydroxide; sodium azide; hydrogen; nickel; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00088a011