(R)-(-)-1-Cbz-3-pyrrolidinol

Base Information Edit

Chemical Name:(R)-(-)-1-Cbz-3-pyrrolidinol
CAS No.:100858-33-1
Molecular Formula:C12H15NO3
Molecular Weight:221.256
Hs Code.:29339900
European Community (EC) Number:625-155-7
DSSTox Substance ID:DTXSID20457976
Nikkaji Number:J1.224.380D
Wikidata:Q72516459
Mol file:100858-33-1.mol

Synonyms:100858-33-1;(R)-(-)-1-Cbz-3-pyrrolidinol;benzyl (3R)-3-hydroxypyrrolidine-1-carboxylate;(R)-1-CBZ-3-PYRROLIDINOL;(R)-1-Carbobenzoxy-3-pyrrolidinol;1-PYRROLIDINECARBOXYLIC ACID, 3-HYDROXY-, PHENYLMETHYL ESTER, (3R)-;(R)-1-Benzyloxycarbonyl-3-pyrrolidinol;(R)-Benzyl 3-hydroxypyrrolidine-1-carboxylate;(R)-(-)-1-Cbz-3-Hydroxy-pyrrolidine;(R)-N-Cbz-3-hydroxypyrrolidine;MFCD07368258;benzyl (R)-3-hydroxypyrrolidine-1-carboxylate;(R)-N-Z-3-Pyrrolidinol;3-Hydroxy-Cbz-(R)Pyrrolidine;AMY908;SCHEMBL1841984;3-Hydroxy-Cbz-(R)-pyrrolidine;(R)-3-Hydroxy-pyrrolidine-1-carboxylic acid benzyl ester;DTXSID20457976;MBLJFGOKYTZKMH-LLVKDONJSA-N;AKOS016842292;CS-W003377;DS-0808;FS-2448;(R)-1-Carbobenzoxy-3-hydroxypyrrolidine;AC-22438;(R)-(-)-1-Cbz-3-pyrrolidinol, 95%;(R)-N-benzyloxycarbonyl-3-hydroxypyrrolidine;C2585;n-benzyloxycarbonyl-(r)-3-hydroxypyrrolidine;(3R)-N-benzyloxycarbonyl-3-hydroxypyrrolidine;(3R)-N- benzyloxycarbonyl-3-hydroxypyrrolidine;benzyl (R)-3-hydroxy-pyrrolidine-1-carboxylate;Benzyl(3R)-3-hydroxypyrrolidine-1-carboxylate;Benzyl (3R)-3-hydroxy-1-pyrrolidinecarboxylate;EN300-5459589;J-000239;3alpha-Hydroxypyrrolidine-1-carboxylic acid benzyl ester;(R)-3-hydroxy-1-pyrrolidinecarboxylic acid, phenylmethyl ester;(3R)-3-HYDROXY-1-PYRROLIDINECARBOXYLICACID PHENYLMETHYL ESTER;(R)-benzyl 3-hydroxypyrrolidine-1-carboxylate;(R)-(-)-1-CBZ-3-HYDROXY-PYRROLIDINE

Suppliers and Price of (R)-(-)-1-Cbz-3-pyrrolidinol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-(-)-1-Cbz-3-pyrrolidinol
100mg
$ 75.00

TCI Chemical
(R)-1-Carbobenzoxy-3-pyrrolidinol >98.0%(GC)
5g
$ 207.00

TCI Chemical
(R)-1-Carbobenzoxy-3-pyrrolidinol >98.0%(GC)
1g
$ 42.00

SynQuest Laboratories
(R)-1-Cbz-3-hydroxypyrrolidine
1 g
$ 38.00

SynQuest Laboratories
(R)-1-Cbz-3-hydroxypyrrolidine
5 g
$ 58.00

SynQuest Laboratories
(R)-1-Cbz-3-hydroxypyrrolidine
25 g
$ 150.00

Sigma-Aldrich
(R)-(?)-1-Cbz-3-pyrrolidinol 95%
5g
$ 352.00

Sigma-Aldrich
(R)-(?)-1-Cbz-3-pyrrolidinol 95%
1g
$ 93.10

Oakwood
(R)-(-)-1-Cbz-3-Hydroxy-pyrrolidine
5g
$ 20.00

Oakwood
(R)-(-)-1-Cbz-3-Hydroxy-pyrrolidine
1g
$ 10.00

Total 85 raw suppliers

Chemical Property of (R)-(-)-1-Cbz-3-pyrrolidinol Edit

Chemical Property:

Vapor Pressure:3.75E-06mmHg at 25°C
Melting Point:74-79 °C
Refractive Index:1.589
Boiling Point:370.7 °C at 760 mmHg
PKA:14.72±0.20(Predicted)
Flash Point:178 °C
PSA：49.77000
Density:1.263 g/cm³
LogP:1.32770
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Solubility.:soluble in Chloroform
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:221.10519334
Heavy Atom Count:16
Complexity:238

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-(-)-1-Cbz-3-pyrrolidinol ^*data from reagent suppliers

Safty Information:

Pictogram(s): T
Hazard Codes:T
Statements: 25-36/37/38
Safety Statements: 26-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CC1O)C(=O)OCC2=CC=CC=C2
Isomeric SMILES:C1CN(C[C@@H]1O)C(=O)OCC2=CC=CC=C2

Technology Process of (R)-(-)-1-Cbz-3-pyrrolidinol

There total 14 articles about (R)-(-)-1-Cbz-3-pyrrolidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 40499-83-0,83220-72-8,100243-39-8,2799-21-5
(3R)-pyrrolidinol

: 501-53-1,94274-21-2
benzyl chloroformate

: 100858-33-1
(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: With sodium carbonate; In diethyl ether; water; at 0 - 20 ℃;
DOI:10.1021/jo010753j

Reference yield: 95.0%

: 104706-47-0,111810-68-5
(R)-3-hydroxypyrrolidine hydrochloride

: 501-53-1,94274-21-2
benzyl chloroformate

: 100858-33-1
(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: With sodium hydroxide; at 5 ℃; for 2h;
DOI:10.1021/jm00088a011

Reference yield: 84.0%

: 130312-02-6
benzyl 3-oxopyrrolidine-1-carboxylate

: 100858-33-1
(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: With recombinant Chryseobacterium sp. CA 49 ketoreductase; nicotinamide adenine dinucleotide; In aq. phosphate buffer; isopropyl alcohol; at 40 ℃; for 24h; pH=7.0; stereoselective reaction; Enzymatic reaction;
DOI:10.1016/j.procbio.2017.03.002