{2-[(Z)-1-Benzenesulfonyl-2-(4-chloro-phenyl)-vinyl]-phenyl}-methyl-amine

Base Information

Chemical Name:{2-[(Z)-1-Benzenesulfonyl-2-(4-chloro-phenyl)-vinyl]-phenyl}-methyl-amine
CAS No.:869301-71-3
Molecular Formula:C₂₁H₁₈ClNO₂S
Molecular Weight:383.898
Hs Code.:

Synonyms:{2-[(Z)-1-Benzenesulfonyl-2-(4-chloro-phenyl)-vinyl]-phenyl}-methyl-amine

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Chemical Property of {2-[(Z)-1-Benzenesulfonyl-2-(4-chloro-phenyl)-vinyl]-phenyl}-methyl-amine

Chemical Property:

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Technology Process of {2-[(Z)-1-Benzenesulfonyl-2-(4-chloro-phenyl)-vinyl]-phenyl}-methyl-amine

There total 8 articles about {2-[(Z)-1-Benzenesulfonyl-2-(4-chloro-phenyl)-vinyl]-phenyl}-methyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {2-[1-benzenesulfonyl-2-(4-chloro-phenyl)-vinyl]-phenyl}-methyl-carbamic acid tert-butyl ester

: 869301-71-3
{2-[(Z)-1-Benzenesulfonyl-2-(4-chloro-phenyl)-vinyl]-phenyl}-methyl-amine

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 2h;
DOI:10.1021/ol051826e

Reference yield:

: 240493-90-7
tert-butyl (2-(hydroxymethyl)phenyl)(methyl)carbamate

: 869301-71-3
{2-[(Z)-1-Benzenesulfonyl-2-(4-chloro-phenyl)-vinyl]-phenyl}-methyl-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 84 percent / Ph₃P; N-bromosuccinimide / tetrahydrofuran / 2 h / 20 °C

2.1: 88 percent / dimethylformamide / 12 h / 80 °C

3.1: LHMDS / tetrahydrofuran / 0.5 h / -78 °C

3.2: tetrahydrofuran / 1 h / -78 °C

4.1: tetrahydrofuran / 2 h / 20 °C

5.1: 1.33 g / t-BuOK / tetrahydrofuran / 1 h / 0 °C

6.1: 0.614 g / aq. HCl / ethyl acetate / 2 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; potassium tert-butylate; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ol051826e

Reference yield:

: 240493-91-8
(2-bromomethyl-phenyl)-methyl-carbamic acid tert-butyl ester

: 869301-71-3
{2-[(Z)-1-Benzenesulfonyl-2-(4-chloro-phenyl)-vinyl]-phenyl}-methyl-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 88 percent / dimethylformamide / 12 h / 80 °C

2.1: LHMDS / tetrahydrofuran / 0.5 h / -78 °C

2.2: tetrahydrofuran / 1 h / -78 °C

3.1: tetrahydrofuran / 2 h / 20 °C

4.1: 1.33 g / t-BuOK / tetrahydrofuran / 1 h / 0 °C

5.1: 0.614 g / aq. HCl / ethyl acetate / 2 h / 20 °C

With hydrogenchloride; potassium tert-butylate; lithium hexamethyldisilazane; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ol051826e