(2-(Methylamino)phenyl)methanol

Base Information

• Chemical Name: (2-(Methylamino)phenyl)methanol
• CAS No.: 29055-08-1
• Molecular Formula: C8H11 N O
• Molecular Weight: 137.181
• Hs Code.: 2922199090
• European Community (EC) Number: 825-292-4
• NSC Number: 165606
• UNII: 38SPE8SY6A
• DSSTox Substance ID: DTXSID80304396
• Nikkaji Number: J129.093B
• Wikidata: Q82050286
• Mol file: 29055-08-1.mol

Synonyms:(2-(Methylamino)phenyl)methanol;29055-08-1;Benzenemethanol, 2-(methylamino)-;[2-(Methylamino)phenyl]methanol;(2-METHYLAMINO-PHENYL)-METHANOL;Benzyl alcohol, o-(methylamino)-;2-(Methylamino)benzenemethanol;o-(Methylamino)benzyl alcohol;NSC-165606;NSC165606;38SPE8SY6A;2-(Methylamino)benzyl alcohol;SCHEMBL1066003;DTXSID80304396;AMY27184;MFCD09031020;AKOS012390930;DS-7027;CS-0151025;FT-0755713;C74490;EN300-260814;A924144;F8883-2695

Chemical Property of (2-(Methylamino)phenyl)methanol

Chemical Property:

• Vapor Pressure: 0.00143mmHg at 25°C
• Boiling Point: 284.1°Cat760mmHg
• Flash Point: 149°C
• PSA: 32.26000
• Density: 1.117g/cm³
• LogP: 1.29360
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 137.084063974
• Heavy Atom Count: 10
• Complexity: 95.3

Purity/Quality:

≥95% ^*data from raw suppliers

[2-(methylamino)phenyl]methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1=CC=CC=C1CO

Technology Process of (2-(Methylamino)phenyl)methanol

There total 17 articles about (2-(Methylamino)phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Methyl N-methylanthranilate (85-91-6) → N-methyl-o-aminobenzyl alcohol (29055-08-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2.33h; Inert atmosphere;

DOI:10.1021/jacs.0c07490

Reference yield: 100.0%

→ N-methyl-o-aminobenzyl alcohol (29055-08-1)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1248/cpb.39.1746

Reference yield: 93.0%

2-Aminobenzyl alcohol (5344-90-1) + methanol (67-56-1) → N-methyl-o-aminobenzyl alcohol (29055-08-1)

Guidance literature:

With potassium tert-butylate; C₄₉H₅₀Cl₂Ir₂N₅O⁽¹⁺⁾*F₆P^(1-); at 130 ℃; for 4h;

DOI:10.1021/acs.organomet.0c00464

upstream raw materials:

N-Methylisatoic anhydride

1-methyl-2-vinylpyridinium iodide

Methyl N-methylanthranilate

cyclo-(N-methyl)-Amb-d4T-phosphormidate

Downstream raw materials:

{[(2-Hydroxymethyl-phenyl)-methyl-carbamoyl]-methyl}-carbamic acid benzyl ester

N-methyl-2-benzoxymethylbenzaniline

ethyl 3-{N-[2-(hydroxymethyl)phenyl]-N-methylcarbamoyl}acrylate

2-[(2-methylamino)benzylthio]imidazole

Refernces

• 1、 Huang, Shuang,Hong, Xi,Cui, He-Zhen,Zhan, Bing,Li, Zhi-Ming,Hou, Xiu-Feng. "Bimetallic Bis-NHC-Ir(III) Complex Bearing 2-Arylbenzo[d]oxazolyl Ligand: Synthesis, Catalysis, and Bimetallic Effects". . p. 3514 - 3523. Retrieved 2020/10/09.
• 2、 Ji, Xiaochen,Li, Dongdong,Wang, Zhongzhen,Tan, Muyun,Huang, Huawen,Deng, Guo-Jun. "Aerobic C–C Bond Cleavage of Indoles by Visible-Light Photoredox Catalysis with Ru(bpy)32+". . p. 6652 - 6659. Retrieved 2017/12/15.