methyl 4-((6-(2-(dimethylamino)-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)carbamoyl)benzoate

Base Information

Chemical Name:methyl 4-((6-(2-(dimethylamino)-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)carbamoyl)benzoate
CAS No.:1351956-82-5
Molecular Formula:C₂₅H₂₇N₅O₃S
Molecular Weight:477.587
Hs Code.:

Synonyms:methyl 4-((6-(2-(dimethylamino)-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)carbamoyl)benzoate

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Chemical Property of methyl 4-((6-(2-(dimethylamino)-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)carbamoyl)benzoate

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Technology Process of methyl 4-((6-(2-(dimethylamino)-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)carbamoyl)benzoate

There total 8 articles about methyl 4-((6-(2-(dimethylamino)-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)carbamoyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1679-64-7
Monomethyl terephthalate

: 1351956-54-1
6-(2-(dimethylamino)-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-amine

: 1351956-82-5
methyl 4-((6-(2-(dimethylamino)-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)carbamoyl)benzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1351956-60-9
4-(2-(dimethylamino)-1-(1H-imidazol-1-yl)butyl)aniline

: 1351956-82-5
methyl 4-((6-(2-(dimethylamino)-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)carbamoyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: bromine; acetic acid / 1 h / 7 - 20 °C

2: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With bromine; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide;

Reference yield:

: 13211-00-2
N-(4-butyrylphenyl)acetamide

: 1351956-82-5
methyl 4-((6-(2-(dimethylamino)-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)carbamoyl)benzoate

Guidance literature:: Multi-step reaction with 7 steps

1: aluminum (III) chloride; bromine / dichloromethane / 3.5 h / 0 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / chloroform; methanol / 48 h / 20 °C

3: sodium tetrahydroborate; methanol / 20 °C / Inert atmosphere; Cooling with ice

4: acetonitrile / Reflux

5: hydrogenchloride / water / 60 °C

6: bromine; acetic acid / 1 h / 7 - 20 °C

7: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; methanol; aluminum (III) chloride; sodium tetrahydroborate; bromine; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile;