(2S)-2-hydroxy-3-mono-p-methoxytrityl-N,N-tetramethylenepropanamide

Base Information

• Chemical Name: (2S)-2-hydroxy-3-mono-p-methoxytrityl-N,N-tetramethylenepropanamide
• CAS No.: 213458-69-6
• Molecular Formula: C₂₇H₂₉NO₄
• Molecular Weight: 431.532
• Mol file: 213458-69-6.mol

Synonyms:(2S)-2-hydroxy-3-mono-p-methoxytrityl-N,N-tetramethylenepropanamide

Chemical Property of (2S)-2-hydroxy-3-mono-p-methoxytrityl-N,N-tetramethylenepropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-2-hydroxy-3-mono-p-methoxytrityl-N,N-tetramethylenepropanamide

There total 2 articles about (2S)-2-hydroxy-3-mono-p-methoxytrityl-N,N-tetramethylenepropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(2S)-2,3-dihydroxy-N,N-tetramethylenepropanamide (213458-65-2) + mono-4-methoxytrityl chloride (14470-28-1) → (2S)-2-hydroxy-3-mono-p-methoxytrityl-N,N-tetramethylenepropanamide (213458-69-6)

Guidance literature:

With pyridine; dmap; for 7h; Ambient temperature;

DOI:10.1021/ja981812m

Reference yield:

(2S)-2,3-O-isopropylidene-N,N-tetramethylenepropanamide (213458-64-1) → (2S)-2-hydroxy-3-mono-p-methoxytrityl-N,N-tetramethylenepropanamide (213458-69-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent aq. AcOH / 12 h / 35 °C

2: 85 percent / pyridine, DMAP / 7 h / Ambient temperature

With pyridine; dmap; acetic acid;

DOI:10.1021/ja981812m

Reference yield:

p-phenylbenzylmagnesium chloride (130387-76-7) + (2S)-2-hydroxy-3-mono-p-methoxytrityl-N,N-tetramethylenepropanamide (213458-69-6) + 4-Nitrobenzenesulfonyl chloride (98-74-8) → 4-nitro-benzenesulfonic acid 3-azido-4-biphenyl-4-yl-2-hydroxy-butyl ester

Guidance literature:

Multistep reaction;

DOI:10.1021/ja981812m

upstream raw materials:

(2S)-2,3-dihydroxy-N,N-tetramethylenepropanamide

mono-4-methoxytrityl chloride

(2S)-2,3-O-isopropylidene-N,N-tetramethylenepropanamide