2,2,2-Trifluoro-N-(2-{4-[5-(4-methyl-piperazin-1-yl)-1H,1'H-[2,5']bibenzoimidazolyl-2'-yl]-phenoxy}-ethyl)-acetamide

Base Information

• Chemical Name: 2,2,2-Trifluoro-N-(2-{4-[5-(4-methyl-piperazin-1-yl)-1H,1'H-[2,5']bibenzoimidazolyl-2'-yl]-phenoxy}-ethyl)-acetamide
• CAS No.: 179749-11-2
• Molecular Formula: C₂₉H₂₈F₃N₇O₂
• Molecular Weight: 563.582
• Mol file: 179749-11-2.mol

Synonyms:2,2,2-Trifluoro-N-(2-{4-[5-(4-methyl-piperazin-1-yl)-1H,1'H-[2,5']bibenzoimidazolyl-2'-yl]-phenoxy}-ethyl)-acetamide

Chemical Property of 2,2,2-Trifluoro-N-(2-{4-[5-(4-methyl-piperazin-1-yl)-1H,1'H-[2,5']bibenzoimidazolyl-2'-yl]-phenoxy}-ethyl)-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,2-Trifluoro-N-(2-{4-[5-(4-methyl-piperazin-1-yl)-1H,1'H-[2,5']bibenzoimidazolyl-2'-yl]-phenoxy}-ethyl)-acetamide

There total 2 articles about 2,2,2-Trifluoro-N-(2-{4-[5-(4-methyl-piperazin-1-yl)-1H,1'H-[2,5']bibenzoimidazolyl-2'-yl]-phenoxy}-ethyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

4-[2-(2,2,2-Trifluoro-acetylamino)-ethoxy]-benzimidic acid methyl ester (179749-10-1) + 2-amino-4-<5'-(4''-methylpiperazin-1''-yl)benzimidazol-2'-yl>aniline (23491-49-8) → 2,2,2-Trifluoro-N-(2-{4-[5-(4-methyl-piperazin-1-yl)-1H,1'H-[2,5']bibenzoimidazolyl-2'-yl]-phenoxy}-ethyl)-acetamide (179749-11-2)

Guidance literature:

With acetic acid; In methanol; at 65 - 70 ℃; for 3h; Heating;

DOI:10.1021/ja960948m

Reference yield:

N-[2-(4-Cyano-phenoxy)-ethyl]-2,2,2-trifluoro-acetamide → 2,2,2-Trifluoro-N-(2-{4-[5-(4-methyl-piperazin-1-yl)-1H,1'H-[2,5']bibenzoimidazolyl-2'-yl]-phenoxy}-ethyl)-acetamide (179749-11-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / HCl / CH₂Cl₂ / 0 h

2: 45 percent / AcOH / methanol / 3 h / 65 - 70 °C / Heating

With hydrogenchloride; acetic acid; In methanol; dichloromethane;

DOI:10.1021/ja960948m

Reference yield: 94.0%

2,2,2-Trifluoro-N-(2-{4-[5-(4-methyl-piperazin-1-yl)-1H,1'H-[2,5']bibenzoimidazolyl-2'-yl]-phenoxy}-ethyl)-acetamide (179749-11-2) → 2-{4-[5-(4-Methyl-piperazin-1-yl)-1H,1'H-[2,5']bibenzoimidazolyl-2'-yl]-phenoxy}-ethylamine (179749-12-3)

Guidance literature:

With potassium carbonate; In methanol; Ambient temperature;

DOI:10.1021/ja960948m

upstream raw materials:

4-[2-(2,2,2-Trifluoro-acetylamino)-ethoxy]-benzimidic acid methyl ester

2-amino-4-<5'-(4''-methylpiperazin-1''-yl)benzimidazol-2'-yl>aniline

Downstream raw materials:

2-{4-[5-(4-Methyl-piperazin-1-yl)-1H,1'H-[2,5']bibenzoimidazolyl-2'-yl]-phenoxy}-ethylamine