5-[5-((S)-1-{(S)-2-[(S)-2-((tert-butoxycarbonyl)(methyl)amino)propionylamino]-2-cyclohexylacetyl}pyrrolidin-2-yl)-pyridin-3-yl]-2-fluorobenzoic acid

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Chemical Name:5-[5-((S)-1-{(S)-2-[(S)-2-((tert-butoxycarbonyl)(methyl)amino)propionylamino]-2-cyclohexylacetyl}pyrrolidin-2-yl)-pyridin-3-yl]-2-fluorobenzoic acid
CAS No.:1381963-37-6
Molecular Formula:C₃₃H₄₃FN₄O₆
Molecular Weight:610.726
Hs Code.:

Synonyms:5-[5-((S)-1-{(S)-2-[(S)-2-((tert-butoxycarbonyl)(methyl)amino)propionylamino]-2-cyclohexylacetyl}pyrrolidin-2-yl)-pyridin-3-yl]-2-fluorobenzoic acid

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Chemical Property of 5-[5-((S)-1-{(S)-2-[(S)-2-((tert-butoxycarbonyl)(methyl)amino)propionylamino]-2-cyclohexylacetyl}pyrrolidin-2-yl)-pyridin-3-yl]-2-fluorobenzoic acid

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Technology Process of 5-[5-((S)-1-{(S)-2-[(S)-2-((tert-butoxycarbonyl)(methyl)amino)propionylamino]-2-cyclohexylacetyl}pyrrolidin-2-yl)-pyridin-3-yl]-2-fluorobenzoic acid

There total 1 articles about 5-[5-((S)-1-{(S)-2-[(S)-2-((tert-butoxycarbonyl)(methyl)amino)propionylamino]-2-cyclohexylacetyl}pyrrolidin-2-yl)-pyridin-3-yl]-2-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 872460-12-3
5-(dihydroxyboranyl)-2-fluorobenzoic acid

: 1020176-96-8
((S)-1-{(S)-2-[(S)-2-(5-Bromo-pyridin-3-yl)-pyrrolidin-1-yl]-1-cyclohexyl-2-oxo-ethylcarbamoyl}-ethyl)-methyl-carbamic acid tert-butyl ester

: 1381963-37-6
5-[5-((S)-1-{(S)-2-[(S)-2-((tert-butoxycarbonyl)(methyl)amino)propionylamino]-2-cyclohexylacetyl}pyrrolidin-2-yl)-pyridin-3-yl]-2-fluorobenzoic acid

Guidance literature:: 5-(dihydroxyboranyl)-2-fluorobenzoic acid; ((S)-1-{(S)-2-[(S)-2-(5-Bromo-pyridin-3-yl)-pyrrolidin-1-yl]-1-cyclohexyl-2-oxo-ethylcarbamoyl}-ethyl)-methyl-carbamic acid tert-butyl ester; With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In ethanol; water; toluene; at 80 ℃; for 3h; Inert atmosphere;

With hydrogenchloride; In water; pH=3;

Reference yield: 33.0%

: 1381963-37-6
5-[5-((S)-1-{(S)-2-[(S)-2-((tert-butoxycarbonyl)(methyl)amino)propionylamino]-2-cyclohexylacetyl}pyrrolidin-2-yl)-pyridin-3-yl]-2-fluorobenzoic acid

: 107-15-3,85404-18-8
ethylenediamine

: 1381963-38-7
C₆₈H₉₀F₂N₁₀O₁₀

Guidance literature:: 5-[5-((S)-1-{(S)-2-[(S)-2-((tert-butoxycarbonyl)(methyl)amino)propionylamino]-2-cyclohexylacetyl}pyrrolidin-2-yl)-pyridin-3-yl]-2-fluorobenzoic acid; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; Inert atmosphere; Cooling with ice bath;

ethylenediamine; With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 869308-34-9
1,19-diamino-4,7,10,13,16-pentaoxanonadecane

: 1381963-37-6
5-[5-((S)-1-{(S)-2-[(S)-2-((tert-butoxycarbonyl)(methyl)amino)propionylamino]-2-cyclohexylacetyl}pyrrolidin-2-yl)-pyridin-3-yl]-2-fluorobenzoic acid

: 76-05-1
trifluoroacetic acid

: 5-(5-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)pyridin-3-yl)-N-(1-(5-(5-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)pyridin-3-yl)-2-fluorophenyl)-1-oxo-6,9,12,15,18-pentaoxa-2-azahenicosan-21-yl)-2-fluorobenzamide tetra-trifluoroacetate

Guidance literature:: 5-[5-((S)-1-{(S)-2-[(S)-2-((tert-butoxycarbonyl)(methyl)amino)propionylamino]-2-cyclohexylacetyl}pyrrolidin-2-yl)-pyridin-3-yl]-2-fluorobenzoic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h;

1,19-diamino-4,7,10,13,16-pentaoxanonadecane; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

trifluoroacetic acid;