N^α-Fmoc-D-Val-Leu-N^ε-Fmoc-Lys benzyl ester

Base Information

• Chemical Name: N^α-Fmoc-D-Val-Leu-N^ε-Fmoc-Lys benzyl ester
• CAS No.: 84624-18-0
• Molecular Formula: C₅₄H₆₀N₄O₈
• Molecular Weight: 893.092
• Mol file: 84624-18-0.mol

Synonyms:N^α-Fmoc-D-Val-Leu-N^ε-Fmoc-Lys benzyl ester

Chemical Property of N^α-Fmoc-D-Val-Leu-N^ε-Fmoc-Lys benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-Fmoc-D-Val-Leu-N^ε-Fmoc-Lys benzyl ester

There total 4 articles about N^α-Fmoc-D-Val-Leu-N^ε-Fmoc-Lys benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid benzyl ester; compound with trifluoro-acetic acid + N-(9-fluorenylmethoxycarbonyl)-D-valine (84624-17-9) → Nα-Fmoc-D-Val-Leu-Nε-Fmoc-Lys benzyl ester (84624-18-0)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 10h;

DOI:10.1021/jm00359a004

Reference yield: 52.0%

D-(N-9-fluorenylmethoxycarbonylvalyl)-L-leucine (84624-20-4) + Nε-Fmoc-Lys benzyl eater p-toluenesulfonate (84624-14-6) → Nα-Fmoc-D-Val-Leu-Nε-Fmoc-Lys benzyl ester (84624-18-0)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 14h;

DOI:10.1021/jm00359a004

Reference yield:

N-(9-fluorenylmethoxycarbonyl)-D-valine (84624-17-9) → Nα-Fmoc-D-Val-Leu-Nε-Fmoc-Lys benzyl ester (84624-18-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 55 percent / N-methylmorpholine, 1-hydroxybenzotriazole (HOBT*H₂O), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 14 h / 0 - 25 °C

2: 98 percent / 27percent HBr / acetic acid / 3 h / Ambient temperature

3: 52 percent / N-methylmorpholine, 1-hydroxybenzotriazole (HOBT*H₂O), 1-ethyl-3<3-(dimethylamino)propyl>carbodiimine hydrochloride / dimethylformamide / 14 h / 0 - 25 °C

With 4-methyl-morpholine; hydrogen bromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm00359a004

upstream raw materials:

D-(N-9-fluorenylmethoxycarbonylvalyl)-L-leucine

N^ε-Fmoc-Lys benzyl eater p-toluenesulfonate

N-(9-fluorenylmethoxycarbonyl)-D-valine

N^α-Fmoc-D-Val-Leu benzyl ester

Refernces