4-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-3-n-butyl-5-<<(methoxycarbonyl)methyl>thio>-4H-1,2,4-triazole

Base Information

Chemical Name:4-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-3-n-butyl-5-<<(methoxycarbonyl)methyl>thio>-4H-1,2,4-triazole
CAS No.:134425-16-4
Molecular Formula:C₂₇H₃₃N₃O₄S
Molecular Weight:495.643
Hs Code.:

Synonyms:4-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-3-n-butyl-5-<<(methoxycarbonyl)methyl>thio>-4H-1,2,4-triazole

Suppliers and Price of 4-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-3-n-butyl-5-<<(methoxycarbonyl)methyl>thio>-4H-1,2,4-triazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-3-n-butyl-5-<<(methoxycarbonyl)methyl>thio>-4H-1,2,4-triazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-3-n-butyl-5-<<(methoxycarbonyl)methyl>thio>-4H-1,2,4-triazole

There total 7 articles about 4-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-3-n-butyl-5-<<(methoxycarbonyl)methyl>thio>-4H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 96-34-4
methyl chloroacetate

: 133690-76-3
4-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-5-n-butyl-2,4-dihydro-3H-1,2,4-triazole-3-thione

: 134425-16-4
4-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-3-n-butyl-5-<<(methoxycarbonyl)methyl>thio>-4H-1,2,4-triazole

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 7.5h; Ambient temperature;
DOI:10.1021/jm00057a009

Reference yield:

: 114772-40-6
4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester

: 134425-16-4
4-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-3-n-butyl-5-<<(methoxycarbonyl)methyl>thio>-4H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / dimethylformamide / 7 h / Ambient temperature

2: 1.) hydrazine hydrate, 2.) glacial acetic acid / 1.) EtOH, RT, 7.5 h, 2.) EtOH, RT, overnight

3: Et₃N / methanol / 1.25 h / 30 °C

4: Et₃N / methanol / 2 h / Ambient temperature

5: 79 percent / hydrazine hydrate / ethanol / 2 h / Heating

6: 63 percent / 2-methoxy-ethanol / 24 h / Heating

7: 86 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 7.5 h / Ambient temperature

With hydrazine hydrate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; 2-methoxy-ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00057a009

Reference yield:

: 133690-73-0
4'-(Aminomethyl)[1,1'-biphenyl]-2-carboxylic acid,1,1-dimethylethyl ester

: 134425-16-4
4-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-3-n-butyl-5-<<(methoxycarbonyl)methyl>thio>-4H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / methanol / 1.25 h / 30 °C

2: Et₃N / methanol / 2 h / Ambient temperature

3: 79 percent / hydrazine hydrate / ethanol / 2 h / Heating

4: 63 percent / 2-methoxy-ethanol / 24 h / Heating

5: 86 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 7.5 h / Ambient temperature

With hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; 2-methoxy-ethanol;
DOI:10.1021/jm00057a009