133690-73-0

Basic information

• Product Name: 4'-(AMINOMETHYL)-BIPHENYL-2-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
• Synonyms: 4'-(AMINOMETHYL)-BIPHENYL-2-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER;2-Boc-4'-(aminomethyl)biphenyl HCl
• CAS NO: 133690-73-0
• Molecular Formula: C₁₈H₂₁NO₂
• Molecular Weight: 283.369
• Mol File: 133690-73-0.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4'-(AMINOMETHYL)-BIPHENYL-2-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-(AMINOMETHYL)-BIPHENYL-2-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER(133690-73-0)
• EPA Substance Registry System: 4'-(AMINOMETHYL)-BIPHENYL-2-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER(133690-73-0)

Safety Data

• Hazardous Substances Data: 133690-73-0(Hazardous Substances Data)

Upstream product

• 114772-40-6 4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester 
• 114772-36-0 tert-butyl 4'-methyl-2-biphenylcarboxylate 
• 114772-34-8 methyl 4'-methylbiphenyl-2-carboxylate 
• 7148-03-0 o-tolylbenzoic acid 
• 139476-12-3 4'-(Azidomethyl)[1,1'-biphenyl]-2-carboxylic acid,1,1-dimethylethyl ester 
• 133690-72-9 N-[[2'-(t-Butoxycarbonyl)biphenyl-4-yl]-methyl]phthalimide 

Downstream Products

• 134425-16-4 4-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-3-n-butyl-5-<<(methoxycarbonyl)methyl>thio>-4H-1,2,4-triazole 
• 151257-08-8 tert-butyl-4'-<(2-n-butyl-4-oxo-1,3-diazaspiro<4.4>nonan-3-yl)methyl>biphenyl-2-carboxylate 
• 138401-34-0 tert-butyl-4'-<(2-n-butyl-4-thioxo-1,3-diazaspiro<4.4>non-1-en-3-yl)methyl>biphenyl-2-carboxylate 
• 138401-20-4 tert-butyl-4'-<(2-n-butyl-4-oxo-1,3-diazaspiro<4.4>non-1-en-3-yl)methyl>biphenyl-2-carboxylate 
• 139476-15-6 4'-(1,3-Dibutyl-5-oxo-1,5-dihydro-[1,2,4]triazol-4-ylmethyl)-biphenyl-2-carboxylic acid tert-butyl ester 
• 151257-02-2 tert-butyl 4'-<<<<1-<(fluorenylmethyloxycarbonyl)amino>cyclopentyl>carbonyl>amino>methyl>biphenyl-2-carboxylate 

Relevant articles and documents

N-substituted-1, 2, 4-triazolone compounds for treatment of cardiovascular disorders

A class of N-substituted-1,2,4-triazolone compounds is described for use in treatment of cardiovascular disorders. Compounds of particular interest are angiotensin II antagonists of the formula wherein R1 is selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, 4-methylbutyl, n-pentyl, neopentyl, phenyl, benzyl, phenethyl, cyclohexyl, cyclohexylmethyl, 1-oxoethyl, 1-oxopropyl, 1-oxobutyl, 1-oxopentyl and hydroxyalkyl; wherein R2 is selected from ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, 4-methylbutyl, tert-butyl, n-pentyl, neo-pentyl, propylthio and butylthio; wherein each of R3 through R11 is hydrido with the proviso that at least one of R5 and R9 must be selected from COOH, SH, PO3H2, SO3H, CONHNH2, CONHNHSO2CF3, OH, wherein each of R42 and R43 is independently selected from chloro, cyano, nitro, trifluoromethyl, methoxycarbonyl and trifluoromethylsulfonyl. These compounds are particularly useful in treatment or control of hypertension and congestive heart failure.

SUBSTITUTED 1,2,4-TRIAZOLES BEARING ACIDIC FUNCTIONAL GROUPS AS ANGIOTENSIN II ANTAGONISTS

Novel substituted triazolinone, triazolinethione, and triazolinimine compounds of the formula I are useful as angiotensin II antagonists. STR1

Synthesis and Structure-Activity Relationships of Nonpeptide, Potent Triazolone-Based Angiotensin II Receptor Antagonists

2,5-Dibutyl-2,4-dihydro-4--4'-yl>methyl>-3H-1,2,4-triazol-3-one, SC-51316, was synthesized as a potent and orally active angiotensin II (AII) receptor antagonist with a long duration of action.To explore the lipophilic pocket in the AII receptor interacting with the substituent at the 2-position of triazolone-based antagonists, a series of compounds were prepared and evaluated for receptor binding affinity and antagonism of AII-contracted rabbitaortic rings.It has been found that the pocket is very spacious and can accommodate different sizes of lipophilic groups and various functionalities.Acidic groups generally result in a slight decrease in binding affinity.Branched chains are unfavorable.The freedom of rotation around C2-C3 in the flexible side chain is crucial for good binding.The 2-phenylethyl-substituted triazolone analogue exhibits the highest in vitro potency among all compounds that have been synthesized.