C₂₀H₂₆N₂O₂

Base Information

• Chemical Name: C₂₀H₂₆N₂O₂
• CAS No.: 1452394-31-8
• Molecular Formula: C₂₀H₂₆N₂O₂
• Molecular Weight: 326.439
• Mol file: 1452394-31-8.mol

Synonyms:C₂₀H₂₆N₂O₂

Chemical Property of C₂₀H₂₆N₂O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₆N₂O₂

There total 4 articles about C₂₀H₂₆N₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

C13H18N2O (1452394-25-0) + cyclohex-3-enecarbonyl chloride (932-67-2) → C20H26N2O2 (1452394-31-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Combinatorial reaction / High throughput screening (HTS);

DOI:10.1021/co400078r

Reference yield:

tert-butyl 4-azidopiperidine-1-carboxylate (180695-80-1) → C20H26N2O2 (1452394-31-8)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / 1,4-dioxane / 60 °C

2: potassium carbonate / dimethyl sulfoxide / 18 h / 90 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 30 °C / Flow reactor

4: triethylamine / dichloromethane / 20 °C / Combinatorial reaction / High throughput screening (HTS)

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1021/co400078r

Reference yield:

4-azidopiperidine hydrochloride → C20H26N2O2 (1452394-31-8)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 18 h / 90 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 30 °C / Flow reactor

3: triethylamine / dichloromethane / 20 °C / Combinatorial reaction / High throughput screening (HTS)

With palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In methanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1021/co400078r

upstream raw materials:

tert-butyl 4-azidopiperidine-1-carboxylate

1-(2-(4-azidopiperidin-1-yl)phenyl)ethanone

C₁₃H₁₈N₂O

cyclohex-3-enecarbonyl chloride