Tert-butyl 4-azidopiperidine-1-carboxylate

Base Information

• Chemical Name: Tert-butyl 4-azidopiperidine-1-carboxylate
• CAS No.: 180695-80-1
• Molecular Formula: C10H18N4O2
• Molecular Weight: 226.279
• Hs Code.: 2933399090
• European Community (EC) Number: 803-223-9
• DSSTox Substance ID: DTXSID80466544
• Nikkaji Number: J1.097.791F
• Wikidata: Q82293130
• Mol file: 180695-80-1.mol

Synonyms:tert-butyl 4-azidopiperidine-1-carboxylate;180695-80-1;1-Boc-4-azidopiperidine;MFCD16040162;4-azido-piperidine-1-carboxylic acid tert-butyl ester;tert-butyl 4-azidopiperidine-1-carboxylate(SALTDATA: FREE);SCHEMBL13593444;DTXSID80466544;NKZZRYWSQYJWJG-UHFFFAOYSA-N;4-Azido-1-t-butoxycarbonylpiperidine;4-Azido-N-t butyloxycarbonylpiperidine;AKOS005175018;AB70743;N-tert-butyloxycarbonyl-4-azidopiperidine;LS-04779;SY066056;4-Azido-1-(tert-butoxycarbonyl)piperidine;FT-0683952;EN300-62412;F80427;A812557;A1-01267;tert-Butyl 4-azidopiperidine-1-carboxylate, AldrichCPR;diazonio-[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]azanide

Chemical Property of Tert-butyl 4-azidopiperidine-1-carboxylate

Chemical Property:

• Boiling Point: 140-142 °C
• PSA: 79.29000
• LogP: 2.08686
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 226.14297583
• Heavy Atom Count: 16
• Complexity: 296

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 4-azidopiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCC(CC1)N=[N+]=[N-]

Technology Process of Tert-butyl 4-azidopiperidine-1-carboxylate

There total 7 articles about Tert-butyl 4-azidopiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate (141699-59-4) → tert-butyl 4-azidopiperidine-1-carboxylate (180695-80-1)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 100 ℃;

Reference yield: 99.0%

tert-butyl 4-bromo-1-piperidinecarboxylate (180695-79-8) → tert-butyl 4-azidopiperidine-1-carboxylate (180695-80-1)

Guidance literature:

With Caswell No_. 744A; In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1016/S0960-894X(99)00169-9

Reference yield: 81.0%

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → tert-butyl 4-azidopiperidine-1-carboxylate (180695-80-1)

Guidance literature:

With nicotinoyl azide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1055/s-2004-831254

upstream raw materials:

tert-butyl 4-bromo-1-piperidinecarboxylate

t-butyl 4-hydroxy piperidine-1-carboxylate

1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

4-bromo-1H-piperidine

Downstream raw materials:

tert-butyl 4-(4-phenyl-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate

1-(tert-butoxycarbonyl)-4-aminopiperidine

tert-butyl 4-[(methylcarbamoyl)amino]piperidine-1-carboxylate

4-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)piperidine