2(S)-2-hydroxy-2-phenyl-2-thien-2-ylacetic acid 1-azabicyclo[2.2.2]oct-3(R)-yl ester

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Chemical Name:2(S)-2-hydroxy-2-phenyl-2-thien-2-ylacetic acid 1-azabicyclo[2.2.2]oct-3(R)-yl ester
CAS No.:1185907-21-4
Molecular Formula:C₁₉H₂₁NO₃S
Molecular Weight:343.447
Hs Code.:

Synonyms:2(S)-2-hydroxy-2-phenyl-2-thien-2-ylacetic acid 1-azabicyclo[2.2.2]oct-3(R)-yl ester

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Chemical Property of 2(S)-2-hydroxy-2-phenyl-2-thien-2-ylacetic acid 1-azabicyclo[2.2.2]oct-3(R)-yl ester

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Technology Process of 2(S)-2-hydroxy-2-phenyl-2-thien-2-ylacetic acid 1-azabicyclo[2.2.2]oct-3(R)-yl ester

There total 2 articles about 2(S)-2-hydroxy-2-phenyl-2-thien-2-ylacetic acid 1-azabicyclo[2.2.2]oct-3(R)-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 320348-21-8
oxothien-2-yl-acetic acid 1-azabicyclo[2.2.2]oct-3(R)-yl ester

: 100-58-3
phenylmagnesium bromide

: 1185907-22-5
2(R)-2-hydroxy-2-phenyl-2-thien-2-ylacetic acid 1-azabicyclo[2.2.2]oct-3(R)-yl ester

: 1185907-21-4
2(S)-2-hydroxy-2-phenyl-2-thien-2-ylacetic acid 1-azabicyclo[2.2.2]oct-3(R)-yl ester

Guidance literature:: oxothien-2-yl-acetic acid 1-azabicyclo[2.2.2]oct-3(R)-yl ester; phenylmagnesium bromide; In tetrahydrofuran; at -60 - 20 ℃;

With water; ammonium chloride; In tetrahydrofuran;
DOI:10.1021/jm900132z