Technology Process of 5,7-difluoro-3',4',5'-trihydroxyflavonol
There total 5 articles about 5,7-difluoro-3',4',5'-trihydroxyflavonol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5,7-difluoro-3',4',5'-trimethoxyflavonol;
With
boron tribromide;
In
dichloromethane;
at -78 - 0 ℃;
With
methanol;
In
dichloromethane;
at 20 ℃;
for 0.5h;
DOI:10.1016/j.ejmech.2012.06.031
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium ethanolate / ethanol / 1 h / 20 °C
1.2: 20 °C
1.3: pH 1
2.1: dihydrogen peroxide; sodium hydroxide / methanol; water / 0 - 20 °C
3.1: boron tribromide / dichloromethane / -78 - 0 °C
3.2: 0.5 h / 20 °C
With
dihydrogen peroxide; sodium ethanolate; boron tribromide; sodium hydroxide;
In
methanol; ethanol; dichloromethane; water;
1.1: Claisen Schmidt condensation / 1.2: Claisen Schmidt condensation / 2.1: Algar-Flynn-Olyamada (AFO) reaction;
DOI:10.1016/j.ejmech.2012.06.031
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: dihydrogen peroxide; sodium hydroxide / methanol; water / 0 - 20 °C
2.1: boron tribromide / dichloromethane / -78 - 0 °C
2.2: 0.5 h / 20 °C
With
dihydrogen peroxide; boron tribromide; sodium hydroxide;
In
methanol; dichloromethane; water;
1.1: Algar-Flynn-Olyamada (AFO) reaction;
DOI:10.1016/j.ejmech.2012.06.031
