ethyl [2-methyl-4-({pentyl[4'-(trifluoromethyl)-1,1'-biphenyl-3-yl]amino}sulfonyl)phenoxy]acetate

Base Information

• Chemical Name: ethyl [2-methyl-4-({pentyl[4'-(trifluoromethyl)-1,1'-biphenyl-3-yl]amino}sulfonyl)phenoxy]acetate
• CAS No.: 637352-75-1
• Molecular Formula: C₂₉H₃₂F₃NO₅S
• Molecular Weight: 563.638
• Mol file: 637352-75-1.mol

Synonyms:ethyl [2-methyl-4-({pentyl[4'-(trifluoromethyl)-1,1'-biphenyl-3-yl]amino}sulfonyl)phenoxy]acetate

Chemical Property of ethyl [2-methyl-4-({pentyl[4'-(trifluoromethyl)-1,1'-biphenyl-3-yl]amino}sulfonyl)phenoxy]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl [2-methyl-4-({pentyl[4'-(trifluoromethyl)-1,1'-biphenyl-3-yl]amino}sulfonyl)phenoxy]acetate

There total 5 articles about ethyl [2-methyl-4-({pentyl[4'-(trifluoromethyl)-1,1'-biphenyl-3-yl]amino}sulfonyl)phenoxy]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-pentyl-N-[4'-(trifluoromethyl)-1,1'-biphenyl-3-yl]amine (637352-54-6) + (4-chlorosulfonyl-2-methyl-phenoxy)-acetic acid ethyl ester (91427-62-2) → ethyl [2-methyl-4-({pentyl[4'-(trifluoromethyl)-1,1'-biphenyl-3-yl]amino}sulfonyl)phenoxy]acetate (637352-75-1)

Guidance literature:

With triethylamine; at 20 ℃; for 24h;

Reference yield:

4-trifluoromethylphenylboronic acid (128796-39-4) → ethyl [2-methyl-4-({pentyl[4'-(trifluoromethyl)-1,1'-biphenyl-3-yl]amino}sulfonyl)phenoxy]acetate (637352-75-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 17 h / 95 °C

2: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 17 h / 20 °C

3: triethylamine / 24 h / 20 °C

With sodium tris(acetoxy)borohydride; sodium carbonate; acetic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

3-Iodoaniline (626-01-7) → ethyl [2-methyl-4-({pentyl[4'-(trifluoromethyl)-1,1'-biphenyl-3-yl]amino}sulfonyl)phenoxy]acetate (637352-75-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 17 h / 95 °C

2: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 17 h / 20 °C

3: triethylamine / 24 h / 20 °C

With sodium tris(acetoxy)borohydride; sodium carbonate; acetic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; water;

upstream raw materials:

N-pentyl-N-[4'-(trifluoromethyl)-1,1'-biphenyl-3-yl]amine

(4-chlorosulfonyl-2-methyl-phenoxy)-acetic acid ethyl ester

4'-(trifluoromethyl)-[1,1'-biphenyl]-3-amine

pentanal