4-[(3R)-3-cyano-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-butyryl]-2-methylbenzoic acid tert-butyl ester

Base Information

Chemical Name:4-[(3R)-3-cyano-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-butyryl]-2-methylbenzoic acid tert-butyl ester
CAS No.:1352242-83-1
Molecular Formula:C₂₃H₂₀Cl₂F₃NO₃
Molecular Weight:486.318
Hs Code.:

Synonyms:4-[(3R)-3-cyano-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-butyryl]-2-methylbenzoic acid tert-butyl ester

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Chemical Property of 4-[(3R)-3-cyano-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-butyryl]-2-methylbenzoic acid tert-butyl ester

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Technology Process of 4-[(3R)-3-cyano-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-butyryl]-2-methylbenzoic acid tert-butyl ester

There total 6 articles about 4-[(3R)-3-cyano-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-butyryl]-2-methylbenzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: potassium cyanide

: 1352242-90-0
4-[(E)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-but-2-enoyl]-2-methyl-benzoic acid tert-butyl ester

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 1352242-83-1
4-[(3R)-3-cyano-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-butyryl]-2-methylbenzoic acid tert-butyl ester

Guidance literature:: With cesium chloride; anthracen-9-yl-methyl quininium chloride; In toluene; at 90 ℃; for 18h; Reagent/catalyst; enantioselective reaction; Catalytic behavior;

Reference yield: 79.0%

: potassium cyanide

: 1352242-90-0
4-[(E)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-but-2-enoyl]-2-methyl-benzoic acid tert-butyl ester

: 1352242-83-1
4-[(3R)-3-cyano-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-butyryl]-2-methylbenzoic acid tert-butyl ester

Guidance literature:: With (1S,2S,4S,5R)-1-(anthracen-9-ylmethyl)-2-((R)-hydroxy(quinolin-4-yl)methyl)-5-vinyl-1-azoniabicyclo[2.2.2]octane chloride; cesium chloride; 2-hydroxy-2-methylpropanenitrile; In toluene; at 90 ℃; for 18h; Product distribution / selectivity;

Reference yield: 68.0%

: 1352242-90-0
4-[(E)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-but-2-enoyl]-2-methyl-benzoic acid tert-butyl ester

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 4-[(3S)-3-cyano-3-(3.5-dichloro-phenyl)-4.4.4-trifluorobutanoyl]-2-methylbenzoic acid tert-butyl ester

: 1352242-83-1
4-[(3R)-3-cyano-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-butyryl]-2-methylbenzoic acid tert-butyl ester

Guidance literature:: With potassium carbonate; anthracen-9-yl-methyl quininium chloride; In toluene; at 90 ℃; for 18h; enantioselective reaction;