3-amino-5-(4-chlorophenyl)-8-(diethylamino)-4-imino-3,4-dihydro-5H-chromeno-[2,3-d]pyrimidine

Base Information

• Chemical Name: 3-amino-5-(4-chlorophenyl)-8-(diethylamino)-4-imino-3,4-dihydro-5H-chromeno-[2,3-d]pyrimidine
• CAS No.: 1269625-10-6
• Molecular Formula: C₂₁H₂₂ClN₅O
• Molecular Weight: 395.892
• Mol file: 1269625-10-6.mol

Synonyms:3-amino-5-(4-chlorophenyl)-8-(diethylamino)-4-imino-3,4-dihydro-5H-chromeno-[2,3-d]pyrimidine

Chemical Property of 3-amino-5-(4-chlorophenyl)-8-(diethylamino)-4-imino-3,4-dihydro-5H-chromeno-[2,3-d]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-amino-5-(4-chlorophenyl)-8-(diethylamino)-4-imino-3,4-dihydro-5H-chromeno-[2,3-d]pyrimidine

There total 3 articles about 3-amino-5-(4-chlorophenyl)-8-(diethylamino)-4-imino-3,4-dihydro-5H-chromeno-[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-(4-chlorophenyl)-7-(diethylamino)-2-ethoxymethyleneamino-4H-chromene-3-carbonitrile (1269625-08-2) → 3-amino-5-(4-chlorophenyl)-8-(diethylamino)-4-imino-3,4-dihydro-5H-chromeno-[2,3-d]pyrimidine (1269625-10-6)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 1h;

DOI:10.1016/j.ejmech.2010.12.015

Reference yield:

4-chlorobenzylidenemalonodinitrile (1867-38-5) → 3-amino-5-(4-chlorophenyl)-8-(diethylamino)-4-imino-3,4-dihydro-5H-chromeno-[2,3-d]pyrimidine (1269625-10-6)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine / ethanol / Reflux

2: acetic anhydride / Reflux

3: hydrazine hydrate / ethanol / 20 °C

With piperidine; acetic anhydride; hydrazine hydrate; In ethanol;

DOI:10.3184/174751911X12964930076728

Reference yield:

3-diethylaminophenol (91-68-9) → 3-amino-5-(4-chlorophenyl)-8-(diethylamino)-4-imino-3,4-dihydro-5H-chromeno-[2,3-d]pyrimidine (1269625-10-6)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine / ethanol / Reflux

2: acetic anhydride / Reflux

3: hydrazine hydrate / ethanol / 20 °C

With piperidine; acetic anhydride; hydrazine hydrate; In ethanol;

DOI:10.3184/174751911X12964930076728

upstream raw materials:

4-(4-chlorophenyl)-7-(diethylamino)-2-ethoxymethyleneamino-4H-chromene-3-carbonitrile

4-chlorobenzylidenemalonodinitrile

3-diethylaminophenol

Downstream raw materials:

12-(4-chlorophenyl)-9-diethylamino-2-phenyl-12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine

12-(4-chlorophenyl)-9-diethylamino-12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine

3-ethoxycarbonyl-12-(4-chlorophenyl)-8-diethylamino-4-imino-3,4-dihydro-5H-chromeno[2,3-d]pyrimidine

12-(4-chlorophenyl)-9-diethylamino-2-methyl-12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine