4-(4-chlorophenyl)-7-(diethylamino)-2-ethoxymethyleneamino-4H-chromene-3-carbonitrile

Base Information

• Chemical Name: 4-(4-chlorophenyl)-7-(diethylamino)-2-ethoxymethyleneamino-4H-chromene-3-carbonitrile
• CAS No.: 1269625-08-2
• Molecular Formula: C₂₃H₂₄ClN₃O₂
• Molecular Weight: 409.915
• Mol file: 1269625-08-2.mol

Synonyms:4-(4-chlorophenyl)-7-(diethylamino)-2-ethoxymethyleneamino-4H-chromene-3-carbonitrile

Chemical Property of 4-(4-chlorophenyl)-7-(diethylamino)-2-ethoxymethyleneamino-4H-chromene-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-chlorophenyl)-7-(diethylamino)-2-ethoxymethyleneamino-4H-chromene-3-carbonitrile

There total 3 articles about 4-(4-chlorophenyl)-7-(diethylamino)-2-ethoxymethyleneamino-4H-chromene-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2-amino-4-(4-chlorophenyl)-7-(diethylamino)-4H-chromene-3-carbonitrile (626225-56-7) + acetic anhydride (108-24-7) + orthoformic acid triethyl ester (122-51-0) → 4-(4-chlorophenyl)-7-(diethylamino)-2-ethoxymethyleneamino-4H-chromene-3-carbonitrile (1269625-08-2) + 5-(4-chlorophenyl)-N,N-diethyl-2-methyl-4-oxo-4,5-dihydro-3H-chromeno[2,3-d]-pyrimidin-8-aminium acetate (1269625-09-3)

Guidance literature:

for 3h; Reflux;

DOI:10.1016/j.ejmech.2010.12.015

Reference yield:

4-chlorobenzylidenemalonodinitrile (1867-38-5) → 4-(4-chlorophenyl)-7-(diethylamino)-2-ethoxymethyleneamino-4H-chromene-3-carbonitrile (1269625-08-2)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / ethanol / Reflux

2: acetic anhydride / Reflux

With piperidine; acetic anhydride; In ethanol;

DOI:10.3184/174751911X12964930076728

Reference yield:

3-diethylaminophenol (91-68-9) → 4-(4-chlorophenyl)-7-(diethylamino)-2-ethoxymethyleneamino-4H-chromene-3-carbonitrile (1269625-08-2)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / ethanol / Reflux

2: acetic anhydride / Reflux

With piperidine; acetic anhydride; In ethanol;

DOI:10.3184/174751911X12964930076728

upstream raw materials:

2-amino-4-(4-chlorophenyl)-7-(diethylamino)-4H-chromene-3-carbonitrile

acetic anhydride

orthoformic acid triethyl ester

4-chlorobenzylidenemalonodinitrile

Downstream raw materials:

3-amino-5-(4-chlorophenyl)-8-(diethylamino)-4-imino-3,4-dihydro-5H-chromeno-[2,3-d]pyrimidine

4-amino-5-(4-chlorophenyl)-8-(diethylamino)-5H-chromeno[2,3-d]pyrimidine

2-dimethylaminomethyleneamino-4-(4-chlorophenyl)-7-(diethylamino)-4H-chromene-3-carbonitrile

5-(4-chlorophenyl)-8-(diethylamino)-4-imino-3-methyl-3,4-dihydro-5H-chromeno-[2,3-d]pyrimidine