(3,4-Dichloro-phenyl)-(4-{[(6-fluoro-pyridine-2-ylmethyl)-amino]methyl}-piperidine-1-yl)-methanone

Base Information

• Chemical Name: (3,4-Dichloro-phenyl)-(4-{[(6-fluoro-pyridine-2-ylmethyl)-amino]methyl}-piperidine-1-yl)-methanone
• CAS No.: 208109-29-9
• Molecular Formula: C₁₉H₂₀Cl₂FN₃O
• Molecular Weight: 396.292
• Mol file: 208109-29-9.mol

Synonyms:(3,4-Dichloro-phenyl)-(4-{[(6-fluoro-pyridine-2-ylmethyl)-amino]methyl}-piperidine-1-yl)-methanone

Chemical Property of (3,4-Dichloro-phenyl)-(4-{[(6-fluoro-pyridine-2-ylmethyl)-amino]methyl}-piperidine-1-yl)-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3,4-Dichloro-phenyl)-(4-{[(6-fluoro-pyridine-2-ylmethyl)-amino]methyl}-piperidine-1-yl)-methanone

There total 5 articles about (3,4-Dichloro-phenyl)-(4-{[(6-fluoro-pyridine-2-ylmethyl)-amino]methyl}-piperidine-1-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

4-Aminomethylpiperidine (7144-05-0) + 3,4-dichlorobenzoyl chloride (3024-72-4) + 2-Fluoropyridine-6-carboxaldehyde (208110-81-0) → (3,4-Dichloro-phenyl)-(4-{[(6-fluoro-pyridine-2-ylmethyl)-amino]methyl}-piperidine-1-yl)-methanone (208109-29-9)

Guidance literature:

With Potassium borohydride; triethylamine; In tetrahydrofuran; methanol; water; benzene;

Reference yield:

(3,4-Dichloro-phenyl)-[4-({[1-(6-fluoro-pyridin-2-yl)-meth-(E)-ylidene]-amino}-methyl)-piperidin-1-yl]-methanone → (3,4-Dichloro-phenyl)-(4-{[(6-fluoro-pyridine-2-ylmethyl)-amino]methyl}-piperidine-1-yl)-methanone (208109-29-9)

Guidance literature:

With potassium borohydride; In tetrahydrofuran; methanol; for 4h; Yield given;

DOI:10.1021/jm9804329

Reference yield:

2-fluoro-6-methylpyridine (407-22-7) → (3,4-Dichloro-phenyl)-(4-{[(6-fluoro-pyridine-2-ylmethyl)-amino]methyl}-piperidine-1-yl)-methanone (208109-29-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) t-BuOCH(NMe₂)2, 2.)NaIO₄ / 1.) 140 deg C, 24 h, 2.) H₂O, 25 deg C, p = 80 mbar

2: toluene / 2 h / Heating

3: TEA / tetrahydrofuran / 2 h / Ambient temperature

4: KBH₄ / tetrahydrofuran; methanol / 4 h

With sodium periodate; potassium borohydride; tert-Butoxybis(dimethylamino)methane; TEA; In tetrahydrofuran; methanol; toluene;

DOI:10.1021/jm9804329

upstream raw materials:

2-fluoro-6-methylpyridine

2-Fluoropyridine-6-carboxaldehyde

[1-(6-Fluoro-pyridin-2-yl)-meth-(E)-ylidene]-piperidin-4-ylmethyl-amine

4-Aminomethylpiperidine