[6-({2',6'-dimethyl-4'-[(3-methyloxetan-3-yl)methoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid

Base Information

Chemical Name:[6-({2',6'-dimethyl-4'-[(3-methyloxetan-3-yl)methoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid
CAS No.:1373551-43-9
Molecular Formula:C₃₀H₃₂O₆
Molecular Weight:488.58
Hs Code.:

Synonyms:[6-({2',6'-dimethyl-4'-[(3-methyloxetan-3-yl)methoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid

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Chemical Property of [6-({2',6'-dimethyl-4'-[(3-methyloxetan-3-yl)methoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid

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Technology Process of [6-({2',6'-dimethyl-4'-[(3-methyloxetan-3-yl)methoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid

There total 4 articles about [6-({2',6'-dimethyl-4'-[(3-methyloxetan-3-yl)methoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1373551-42-8
methyl [6-({2',6'-dimethyl-4'-[(3-methyloxetan-3-yl)methoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetate

: 1373551-43-9
[6-({2',6'-dimethyl-4'-[(3-methyloxetan-3-yl)methoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; methanol; at 50 ℃; for 2h;
DOI:10.1021/jm300170m

Reference yield:

: 99314-44-0
(3-methyloxetan-3-yl)methyl 4-methylbenzenesulfonate

: 1373551-43-9
[6-({2',6'-dimethyl-4'-[(3-methyloxetan-3-yl)methoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 70 h / 80 °C / Inert atmosphere

2: methanol; sodium tetrahydroborate / 20 h / 0 - 20 °C / Inert atmosphere

3: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 20 h / 20 °C / Inert atmosphere

4: water; sodium hydroxide / tetrahydrofuran; methanol / 2 h / 50 °C

With methanol; sodium tetrahydroborate; tributylphosphine; water; potassium carbonate; potassium iodide; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; 3: Mitsunobu reaction;
DOI:10.1021/jm300170m

Reference yield:

: 3143-02-0
3-hydroxymethyl-3-methyloxethane

: 1373551-43-9
[6-({2',6'-dimethyl-4'-[(3-methyloxetan-3-yl)methoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 4 h / 0 °C / Inert atmosphere

2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 70 h / 80 °C / Inert atmosphere

3: methanol; sodium tetrahydroborate / 20 h / 0 - 20 °C / Inert atmosphere

4: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 20 h / 20 °C / Inert atmosphere

5: water; sodium hydroxide / tetrahydrofuran; methanol / 2 h / 50 °C

With pyridine; methanol; sodium tetrahydroborate; tributylphosphine; water; potassium carbonate; potassium iodide; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; 4: Mitsunobu reaction;
DOI:10.1021/jm300170m