tert-butyl (((2R,3R)-10-(isonicotinamido)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate

Base Information

Chemical Name:tert-butyl (((2R,3R)-10-(isonicotinamido)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate
CAS No.:1393801-85-8
Molecular Formula:C₃₅H₄₄N₄O₇
Molecular Weight:632.757
Hs Code.:

tert-butyl (((2R,3R)-10-(isonicotinamido)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate

Synonyms:tert-butyl (((2R,3R)-10-(isonicotinamido)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate

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Chemical Property of tert-butyl (((2R,3R)-10-(isonicotinamido)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate

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Technology Process of tert-butyl (((2R,3R)-10-(isonicotinamido)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate

There total 7 articles about tert-butyl (((2R,3R)-10-(isonicotinamido)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14254-57-0
4-(chlorocarbonyl)pyridine

: 1393801-84-7
tert-butyl (((2R,3R)-10-amino-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate

: 1393801-85-8
tert-butyl (((2R,3R)-10-(isonicotinamido)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃;

Reference yield:

: 1255212-71-5
(2S,3R)-4-(tert-butoxycarbonyl(methyl)amino)-3-(tert-butyldimethylsilyloxy)-2-methylbutanoic acid

: 1393801-85-8
tert-butyl (((2R,3R)-10-(isonicotinamido)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 15 h / 3 - 20 °C / Inert atmosphere

2.1: dimethylsulfide borane complex / tetrahydrofuran / 5 h / 65 °C / Inert atmosphere

2.2: 12 h / Reflux

3.1: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

4.1: cesium fluoride / N,N-dimethyl-formamide / 5 h / 85 °C

5.1: hydrogen / palladium on activated charcoal / ethanol / 1.5 h / 40 °C

6.1: 2,6-dimethylpyridine / dichloromethane / 20 °C

With 2,6-dimethylpyridine; dimethylsulfide borane complex; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; cesium fluoride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1255212-85-1
tert-butyl((2R,3R)-2-((tert-butyldimethylsilyl)oxy)-4-(((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)amino)-3-methylbutyl)(methyl)carbamate

: 1393801-85-8
tert-butyl (((2R,3R)-10-(isonicotinamido)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

2: cesium fluoride / N,N-dimethyl-formamide / 5 h / 85 °C

3: hydrogen / palladium on activated charcoal / ethanol / 1.5 h / 40 °C

4: 2,6-dimethylpyridine / dichloromethane / 20 °C

With 2,6-dimethylpyridine; hydrogen; triethylamine; cesium fluoride; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;