Phenyl-acetic acid 4-(2-{4-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenyl ester

Base Information

Chemical Name:Phenyl-acetic acid 4-(2-{4-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenyl ester
CAS No.:73736-57-9
Molecular Formula:C₃₅H₃₅FN₄O₂
Molecular Weight:562.687
Hs Code.:

Synonyms:Phenyl-acetic acid 4-(2-{4-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenyl ester

Suppliers and Price of Phenyl-acetic acid 4-(2-{4-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Phenyl-acetic acid 4-(2-{4-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Phenyl-acetic acid 4-(2-{4-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenyl ester

There total 9 articles about Phenyl-acetic acid 4-(2-{4-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 73736-50-2
O-desmethyl astemizole

: 103-80-0
phenylacetyl chloride

: 73736-57-9
Phenyl-acetic acid 4-(2-{4-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenyl ester

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1021/jm00150a029

Reference yield:

: 73734-07-3
(1H-benzimidazol-2-yl)-(1-ethoxycarbonyl-piperidin-4-yl)amine

: 73736-57-9
Phenyl-acetic acid 4-(2-{4-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 40 percent / sodium carbonate, potassium iodide / dimethylformamide / 70 °C

2: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

3: 46.7 percent / Na₂CO₃ / dimethylformamide / 20 h / 70 °C

4: 88.5 percent / H₂ / 10 percent Pd/C / methanol

5: 18 percent / (C₂H₅)3N / CH₂Cl₂

With hydrogen bromide; hydrogen; sodium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00150a029

Reference yield:

: 84501-68-8
ethyl 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinecarboxylate

: 73736-57-9
Phenyl-acetic acid 4-(2-{4-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

2: 46.7 percent / Na₂CO₃ / dimethylformamide / 20 h / 70 °C

3: 88.5 percent / H₂ / 10 percent Pd/C / methanol

4: 18 percent / (C₂H₅)3N / CH₂Cl₂

With hydrogen bromide; hydrogen; sodium carbonate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00150a029