2-AMINO-3-(3-BROMO-PHENYL)-PROPIONIC ACID

Base Information

• Chemical Name: 2-AMINO-3-(3-BROMO-PHENYL)-PROPIONIC ACID
• CAS No.: 30163-20-3
• Molecular Formula: C9H10BrNO2
• Molecular Weight: 244.088
• Hs Code.: 2922499990
• Mol file: 30163-20-3.mol

Synonyms:DL-Phenylalanine,3-bromo-;2-Amino-3-(3-bromophenyl)propanoic acid;3-Bromo-DL-phenylalanine;

Chemical Property of 2-AMINO-3-(3-BROMO-PHENYL)-PROPIONIC ACID

Chemical Property:

• Vapor Pressure: 4.46E-06mmHg at 25°C
• Refractive Index: 1.608
• Boiling Point: 368.4 °C at 760 mmHg
• PKA: 2.16±0.10(Predicted)
• Flash Point: 176.6 °C
• PSA: 63.32000
• Density: 1.588 g/cm³
• LogP: 2.10380
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99.0%Min ^*data from raw suppliers

DL-3-Bromophenylalanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-3-(3-BROMO-PHENYL)-PROPIONIC ACID

There total 4 articles about 2-AMINO-3-(3-BROMO-PHENYL)-PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl (acetylamino)<(3-bromophenyl)methyl>propanedioate (15017-44-4) → 2-amino-3-(3-bromophenyl)propanoic acid (30163-20-3,99295-78-0)

Guidance literature:

With hydrogenchloride; acetic acid; Heating;

DOI:10.1021/jm00313a013

Reference yield:

meta-bromobenzyl bromide (823-78-9) → 2-amino-3-(3-bromophenyl)propanoic acid (30163-20-3,99295-78-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / NaOEt / ethanol / 5 h / Heating

2: aq. HCl / 16 h / Heating

With hydrogenchloride; sodium ethanolate; In ethanol;

DOI:10.1021/jm050224y

Reference yield:

3-bromocinnamic acid (14473-91-7,20595-41-9,32862-97-8) → 2-amino-3-(3-bromophenyl)propanoic acid (30163-20-3,99295-78-0)

Guidance literature:

With phenylalanine ammonia lyase from Anabaena variabilis; ammonium carbamate; at 30 ℃; for 22h; pH=9.9; Enzymatic reaction;

DOI:10.1002/cctc.201902128

upstream raw materials:

diethyl (acetylamino)<(3-bromophenyl)methyl>propanedioate

meta-bromobenzyl bromide

3-bromocinnamic acid

Downstream raw materials:

Z-DL-Phe(3Br)

Z-DL-Phe(3Br)-OCH₂CF₃

Refernces

• 1、 Liu, Xiangyuan,Liu, Yang,Chai, Guobi,Qiao, Baokun,Zhao, Xiaowei,Jiang, Zhiyong. "Organocatalytic Enantioselective Addition of α-Aminoalkyl Radicals to Isoquinolines". supporting information. p. 6298 - 6301. Retrieved 2018/10/09.
• 2、 DeGraw,Cory,Skinner,Theisen,Mitoma. "Experimentally induced phenylketonuria. I. Inhibitors of phenylalanine hydroxylase.". . p. 64 - 66. Retrieved 2007/10/06.