3-methoxy-2-(2-propenyl)-α-[(5S)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-1-decynyl]benzenemethanol

Base Information

Chemical Name:3-methoxy-2-(2-propenyl)-α-[(5S)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-1-decynyl]benzenemethanol
CAS No.:223734-56-3
Molecular Formula:C₂₆H₃₈O₄
Molecular Weight:414.585
Hs Code.:

Synonyms:3-methoxy-2-(2-propenyl)-α-[(5S)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-1-decynyl]benzenemethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-methoxy-2-(2-propenyl)-α-[(5S)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-1-decynyl]benzenemethanol

Chemical Property:

Purity/Quality:: 98% HPLC ^*data from raw suppliers

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Technology Process of 3-methoxy-2-(2-propenyl)-α-[(5S)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-1-decynyl]benzenemethanol

There total 9 articles about 3-methoxy-2-(2-propenyl)-α-[(5S)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-1-decynyl]benzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 94956-98-6
2-allyl-3-methoxybenzaldehyde

: 223734-62-1
2-[[(1S)-1-(3-butynyl)hexyl]oxy]tetrahydro-2H-pyran

: 223734-56-3
3-methoxy-2-(2-propenyl)-α-[(5S)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-1-decynyl]benzenemethanol

Guidance literature:: With ethylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃;
DOI:10.1021/jo0347720

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 223734-56-3
3-methoxy-2-(2-propenyl)-α-[(5S)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-1-decynyl]benzenemethanol

Guidance literature:: Multi-step reaction with 4 steps

1: TsOH*pyridine / CH₂Cl₂ / 15 h / 20 °C

2: BuLi / tetrahydrofuran; hexane / 15 h / 0 - 20 °C

3: NaOH / ethanol / 20 h / 20 °C

4: 92 percent / EtMgBr / tetrahydrofuran; diethyl ether / 0 - 20 °C

With sodium hydroxide; n-butyllithium; ethylmagnesium bromide; pyridinium p-toluenesulfonate; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane;
DOI:10.1021/jo0347720

Reference yield:

: 6971-51-3
3-methoxybenzyl alcohol

: 223734-56-3
3-methoxy-2-(2-propenyl)-α-[(5S)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-1-decynyl]benzenemethanol

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / imidazole / CH₂Cl₂

2: n-BuLi / hexane / 24 h / 0 - 20 °C

3: 4695 g / TBAF / tetrahydrofuran / 20 °C

4: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

5: 92 percent / EtMgBr / tetrahydrofuran; diethyl ether / 0 - 20 °C

With 1H-imidazole; n-butyllithium; oxalyl dichloride; ethylmagnesium bromide; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; 4: Swern oxidation;
DOI:10.1021/jo0347720