Technology Process of N-benzyl-2-(1H-indole-5-yl)-N-methylethane-1-sulfonamide
There total 19 articles about N-benzyl-2-(1H-indole-5-yl)-N-methylethane-1-sulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 20 ℃;
for 12h;
under 750.075 Torr;
DOI:10.1002/ejoc.201600469
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 86 percent / t-BuOK / tetrahydrofuran / 4.5 h / -78 °C
2: 82 percent / triethylamine; methanesulfonyl chloride / CHCl3 / 25.25 h / 0 - 5 °C
3: 0.7 g / NaI*2H2O / acetone / 6 h / Heating
4: 64 percent / dimethylformamide; SOCl2 / benzene / 5 h / Heating
5: 54 percent / triethylamine / benzene / 5 h / 0 - 20 °C
6: 88 percent / H2 / Pd/C / dioxane / 24 h / 20 °C / 750.06 Torr
7: 84 percent / H2 / Pd/C / ethanol / 8 h / 20 °C
8: 87 percent / triethylamine / CH2Cl2 / 19 h / 0 - 20 °C
9: 51 percent / TiCl4 / chlorobenzene / 0.28 h / 100 - 110 °C
10: 84 percent / KOH / methanol / 2 h / 20 °C
With
potassium hydroxide; thionyl chloride; potassium tert-butylate; hydrogen; titanium tetrachloride; methanesulfonyl chloride; triethylamine; N,N-dimethyl-formamide; sodium iodide;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; chlorobenzene; acetone; benzene;
DOI:10.3987/COM-03-9838
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 100 percent / n-BuLi / tetrahydrofuran; hexane / 4.5 h / -78 °C
2: 85 percent / triethylamine; methanesulfonyl chloride / CH2Cl2 / 24.17 h / 0 - 5 °C
3: 88 percent / H2 / Pd/C / dioxane / 24 h / 20 °C / 750.06 Torr
4: 84 percent / H2 / Pd/C / ethanol / 8 h / 20 °C
5: 87 percent / triethylamine / CH2Cl2 / 19 h / 0 - 20 °C
6: 51 percent / TiCl4 / chlorobenzene / 0.28 h / 100 - 110 °C
7: 84 percent / KOH / methanol / 2 h / 20 °C
With
potassium hydroxide; n-butyllithium; hydrogen; titanium tetrachloride; methanesulfonyl chloride; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; chlorobenzene;
DOI:10.3987/COM-03-9838
