Technology Process of 2-[3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl]ethanesulfonic acid benzylmethylamide
There total 13 articles about 2-[3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl]ethanesulfonic acid benzylmethylamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
methanol;
for 8h;
Heating;
DOI:10.3987/COM-03-9838
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 86 percent / t-BuOK / tetrahydrofuran / 4.5 h / -78 °C
2: 82 percent / triethylamine; methanesulfonyl chloride / CHCl3 / 25.25 h / 0 - 5 °C
3: 0.7 g / NaI*2H2O / acetone / 6 h / Heating
4: 64 percent / dimethylformamide; SOCl2 / benzene / 5 h / Heating
5: 54 percent / triethylamine / benzene / 5 h / 0 - 20 °C
6: 88 percent / H2 / Pd/C / dioxane / 24 h / 20 °C / 750.06 Torr
7: 84 percent / H2 / Pd/C / ethanol / 8 h / 20 °C
8: 87 percent / triethylamine / CH2Cl2 / 19 h / 0 - 20 °C
9: 51 percent / TiCl4 / chlorobenzene / 0.28 h / 100 - 110 °C
10: 84 percent / KOH / methanol / 2 h / 20 °C
11: 83 percent / KOH / methanol / 8 h / Heating
With
potassium hydroxide; thionyl chloride; potassium tert-butylate; hydrogen; titanium tetrachloride; methanesulfonyl chloride; triethylamine; N,N-dimethyl-formamide; sodium iodide;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; chlorobenzene; acetone; benzene;
DOI:10.3987/COM-03-9838
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 100 percent / n-BuLi / tetrahydrofuran; hexane / 4.5 h / -78 °C
2: 85 percent / triethylamine; methanesulfonyl chloride / CH2Cl2 / 24.17 h / 0 - 5 °C
3: 88 percent / H2 / Pd/C / dioxane / 24 h / 20 °C / 750.06 Torr
4: 84 percent / H2 / Pd/C / ethanol / 8 h / 20 °C
5: 87 percent / triethylamine / CH2Cl2 / 19 h / 0 - 20 °C
6: 51 percent / TiCl4 / chlorobenzene / 0.28 h / 100 - 110 °C
7: 84 percent / KOH / methanol / 2 h / 20 °C
8: 83 percent / KOH / methanol / 8 h / Heating
With
potassium hydroxide; n-butyllithium; hydrogen; titanium tetrachloride; methanesulfonyl chloride; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; chlorobenzene;
DOI:10.3987/COM-03-9838
