7-[4-(1-aminocyclobutyl)phenyl]-N-ethyl-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-1-amine

Base Information

Chemical Name:7-[4-(1-aminocyclobutyl)phenyl]-N-ethyl-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-1-amine
CAS No.:1199556-21-2
Molecular Formula:C₂₇H₂₆N₆
Molecular Weight:434.544
Hs Code.:

Synonyms:7-[4-(1-aminocyclobutyl)phenyl]-N-ethyl-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-1-amine

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Chemical Property of 7-[4-(1-aminocyclobutyl)phenyl]-N-ethyl-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-1-amine

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Technology Process of 7-[4-(1-aminocyclobutyl)phenyl]-N-ethyl-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-1-amine

There total 7 articles about 7-[4-(1-aminocyclobutyl)phenyl]-N-ethyl-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl (1-{4-[1-(ethylamino)-8-phenyl-[1,2,4]triazole[4,3-a]-1,5-naphthyridin-7-yl]phenyl}cyclobutyl)carbamate

: 1199556-21-2
7-[4-(1-aminocyclobutyl)phenyl]-N-ethyl-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-1-amine

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 0.5h;

Reference yield:

: 1032349-96-4
tert-butyl [1-(4-chlorophenyl)cyclobutyl]carbamate

: 1199556-21-2
7-[4-(1-aminocyclobutyl)phenyl]-N-ethyl-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-1-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

2.2: -78 - 0 °C

2.3: 0 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 - 120 °C / Inert atmosphere

4.1: hydrazine / 1,4-dioxane / 0.08 h / 100 °C / Microwave irradiation

5.1: tetrahydrofuran / 1 h / 20 °C

5.2: 0.25 h / 120 °C / Microwave irradiation

6.1: trifluoroacetic acid / 0.5 h / 20 °C

With isopropylmagnesium chloride; potassium carbonate; trifluoroacetic acid; hydrazine; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 50921-39-6
1-(4-chlorophenyl)cyclobutane-1-carboxylic acid

: 1199556-21-2
7-[4-(1-aminocyclobutyl)phenyl]-N-ethyl-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-1-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium azide; tetrabutylammomium bromide; zinc trifluoromethanesulfonate / tetrahydrofuran / 18 h / 60 °C / Inert atmosphere

2.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere

3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

3.2: -78 - 0 °C

3.3: 0 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 - 120 °C / Inert atmosphere

5.1: hydrazine / 1,4-dioxane / 0.08 h / 100 °C / Microwave irradiation

6.1: tetrahydrofuran / 1 h / 20 °C

6.2: 0.25 h / 120 °C / Microwave irradiation

7.1: trifluoroacetic acid / 0.5 h / 20 °C

With sodium azide; tetrabutylammomium bromide; isopropylmagnesium chloride; zinc trifluoromethanesulfonate; potassium carbonate; trifluoroacetic acid; hydrazine; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 1.1: Curtius Rearrangement;