2-(2-chloro-5-fluoro-4-methoxyphenyl)-5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,3,4-thiadiazole

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Chemical Name:2-(2-chloro-5-fluoro-4-methoxyphenyl)-5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,3,4-thiadiazole
CAS No.:1228375-40-3
Molecular Formula:C₁₇H₈Cl₂F₄N₄OS
Molecular Weight:463.242
Hs Code.:

Synonyms:2-(2-chloro-5-fluoro-4-methoxyphenyl)-5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,3,4-thiadiazole

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Chemical Property of 2-(2-chloro-5-fluoro-4-methoxyphenyl)-5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,3,4-thiadiazole

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Technology Process of 2-(2-chloro-5-fluoro-4-methoxyphenyl)-5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,3,4-thiadiazole

There total 1 articles about 2-(2-chloro-5-fluoro-4-methoxyphenyl)-5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,3,4-thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.6%

: 1228376-41-7
8-chloro-N'-(2-chloro-5-fluoro-4-methoxybenzoyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carbohydrazide

: 1228375-40-3
2-(2-chloro-5-fluoro-4-methoxyphenyl)-5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,3,4-thiadiazole

Guidance literature:: 8-chloro-N'-(2-chloro-5-fluoro-4-methoxybenzoyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carbohydrazide; With Lawessons reagent; pyridine; In toluene; at 120 ℃; for 4h;

With pyridine; tetraphosphorus decasulfide; at 120 ℃; for 4h;

Reference yield: 70.2%

: 1228375-40-3
2-(2-chloro-5-fluoro-4-methoxyphenyl)-5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,3,4-thiadiazole

: 1228373-01-0
5-chloro-4-{5-[8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]-1,3,4-thiadiazol-2-yl}-2-fluorophenol

Guidance literature:: 2-(2-chloro-5-fluoro-4-methoxyphenyl)-5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,3,4-thiadiazole; With aluminum (III) chloride; In dichloromethane; at 10 ℃;

With ethanethiol; In dichloromethane; at 5 - 10 ℃;