2-(2-Ethoxyphenoxy)ethanamine

Base Information

• Chemical Name: 2-(2-Ethoxyphenoxy)ethanamine
• CAS No.: 6781-17-5
• Molecular Formula: C10H15NO2
• Molecular Weight: 181.235
• Hs Code.: 2922299090
• European Community (EC) Number: 806-760-7
• UNII: 5DRS6GYW0H
• DSSTox Substance ID: DTXSID60415439
• Nikkaji Number: J2.917.652C
• Wikidata: Q82224369
• ChEMBL ID: CHEMBL4580725
• Mol file: 6781-17-5.mol

Synonyms:2-(2-ethoxyphenoxy)ethanamine;6781-17-5;2-(2-ethoxyphenoxy)ethylamine;2-(2-Ethoxy-phenoxy)-ethylamine;Ethanamine, 2-(2-ethoxyphenoxy)-;2-(o-ethoxyphenoxy)ethylamine;1-(2-aminoethoxy)-2-ethoxybenzene;5DRS6GYW0H;Ethanamine,2-(2-ethoxyphenoxy)-;UNII-5DRS6GYW0H;SCHEMBL3347860;beta-(o-Ethoxyphenoxy)ethylamine;CHEMBL4580725;DTXSID60415439;OOKCBENPEIHOJG-UHFFFAOYSA-N;2-(2-ethoxyphenoxy)-1-ethanamine;2-(2-ethoxyphenoxy)ethan-1-amine;MFCD06657756;STK664800;AKOS000136466;CS-W021381;DS-7049;NCGC00334747-01;Tamsulosin hydrochloride impurity F [EP];AMY202003289;.BETA.-(O-ETHOXYPHENOXY)ETHYLAMINE;A9071;FT-0651964;C76145;AB01326566-02;EN300-1841326;A1-03478;TAMSULOSIN HYDROCHLORIDE IMPURITY F [EP IMPURITY]

Chemical Property of 2-(2-Ethoxyphenoxy)ethanamine

Chemical Property:

• Vapor Pressure: 0.0044mmHg at 25°C
• Refractive Index: 1.513
• Boiling Point: 277.9 °C at 760 mmHg
• PKA: 8.55±0.10(Predicted)
• Flash Point: 132.2 °C
• PSA: 44.48000
• Density: 1.04 g/cm³
• LogP: 2.12310
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 181.110278721
• Heavy Atom Count: 13
• Complexity: 130

Purity/Quality:

97% ^*data from raw suppliers

2-(2-Ethoxyphenoxy)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=CC=C1OCCN
• Uses: 2-(2-Ethoxyphenoxy)ethanamine (Tamsulosin EP Impurity F) is an impurity of Tamsulosin (T006350), a specific α1-adrenoceptor antagonist (1,2). It is used in the treatment of benign prostatic hypertrophy.

Technology Process of 2-(2-Ethoxyphenoxy)ethanamine

There total 5 articles about 2-(2-Ethoxyphenoxy)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N-[2-(2-ethoxy-phenoxy)-ethyl]-acetamide → 2-(2-ethoxyphenoxy)-ethylamine (6781-17-5)

Guidance literature:

N-[2-(2-ethoxy-phenoxy)-ethyl]-acetamide; With hydrogenchloride; water; for 4h; Heating / reflux;

With sodium hydroxide; In water; pH=8 - 9;

Reference yield: 61.0%

2-(2-ethoxyphenoxy)acetamide (792931-60-3) → 2-(2-ethoxyphenoxy)-ethylamine (6781-17-5)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 90 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jm400766k

Reference yield:

C18H17NO4 (153334-07-7) → 2-(2-ethoxyphenoxy)-ethylamine (6781-17-5)

Guidance literature:

With water; potassium hydroxide; for 6h; Reflux;

upstream raw materials:

C₁₈H₁₇NO₄

2-(2-ethoxyphenoxy)acetamide

2-Ethoxyphenol

Downstream raw materials:

2-<2-(o-Ethoxy-phenoxy)-ethylamino>-ethanthiol

5-[2-(2-Ethoxy-phenoxy)-ethylamino]-2-isopropyl-2-(3,4,5-trimethoxy-phenyl)-pentanenitrile

(+/-)-Tamsulosin hydrochloride

1-acetyl-5-[2-[2-(2-ethoxyphenoxy)ethylamino]propyl]indoline-7-carbonitrile