Tamsolusin Hydrochloride

Base Information

• Chemical Name: Tamsolusin Hydrochloride
• CAS No.: 80223-99-0
• Molecular Formula: C₂₀H₂₈N₂O₅S*ClH
• Molecular Weight: 444.98
• Hs Code.: 2935909550
• European Community (EC) Number: 617-011-7
• Mol file: 80223-99-0.mol

Synonyms:5-(2-((2-ethoxyphenoxy)ethyl)amino)propyl-2-methoxybenzenesulfonamide;amsulosin;YM 12617;YM-12617

Chemical Property of Tamsolusin Hydrochloride

Chemical Property:

• Vapor Pressure: 3.79E-14mmHg at 25°C
• Melting Point: 228-230℃
• Boiling Point: 595.5 °C at 760 mmHg
• Flash Point: 313.9 °C
• PSA: 108.26000
• LogP: 5.31490
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 11
• Exact Mass: 444.1485709
• Heavy Atom Count: 29
• Complexity: 539

Purity/Quality:

98%,99%, ^*data from raw suppliers

racTamsulosinHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=CC=C1OCCNC(C)CC2=CC(=C(C=C2)OC)S(=O)(=O)N.Cl
• Uses: Tamsulosin is a specific α1-adrenoceptor antagonist. Used in the treatment of benign prostatic hypertrophy. Tamsulosin hydrochloride is a specific ;1-adrenoceptor antagonist. Used in the treatment of benign prostatic hypertrophy.
• Clinical Use: Treatment of benign prostatic hyperplasia
• Drug interactions: Potentially hazardous interactions with other drugs Anaesthetics: enhanced hypotensive effect. Antidepressants: enhanced hypotensive effect with MAOIs. Antifungals: concentration increased by ketoconazole. Avanafil, vardenafil, sildenafil and tadalafil: enhanced hypotensive effect, avoid concomitant use. Beta-blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect. Calcium-channel blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect. Diuretics: enhanced hypotensive effect; increased risk of first dose hypotensive effect. Moxisylyte: possibly severe postural hypotension.

Technology Process of Tamsolusin Hydrochloride

There total 48 articles about Tamsolusin Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.4%

(R)-tamsulosin (106133-20-4,106138-88-9) → tamsulosin hydrochloride (106133-20-4,80223-99-0,128332-25-2)

Guidance literature:

With hydrogenchloride; In methanol; at 45 ℃;

Reference yield: 93.4%

(R)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide hydrochloride (86225-65-2) + 2-(o-ethoxyphenoxy)-ethyl bromide (3259-03-8) → tamsulosin hydrochloride (106133-20-4,80223-99-0,128332-25-2)

Guidance literature:

(R)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide hydrochloride; 2-(o-ethoxyphenoxy)-ethyl bromide; With potassium hydrogencarbonate; potassium iodide; In DMF (N,N-dimethyl-formamide); for 24h; Heating / reflux;

With hydrogenchloride; In methanol; isopropyl alcohol; pH=2;

Reference yield: 93.22%

(R)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide hydrochloride (86225-65-2) + 2-(2-ethyloxyphenoxy)ethyl methanesulfonate (169506-15-4) → tamsulosin hydrochloride (106133-20-4,80223-99-0,128332-25-2)

Guidance literature:

(R)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide hydrochloride; 2-(2-ethyloxyphenoxy)ethyl methanesulfonate; With potassium hydrogencarbonate; potassium iodide; In acetonitrile; for 24h; Heating / reflux;

With hydrogenchloride; In methanol; isopropyl alcohol; pH=2;

upstream raw materials:

(+/-)-Tamsulosin hydrochloride

(+)-Tamsulosin

2-(2-ethoxyphenoxy)ethanol

2-(2-ethyloxyphenoxy)ethyl methanesulfonate

Refernces

• 1、 -. "Preparation method of tamsulosin hydrochloride crystal form". Paragraph 0017-0020. . Retrieved 2021/05/26.
• 2、 -. "Preparation method of tamsulosin hydrochloride". Paragraph 0041; 0046-0047. . Retrieved 2020/07/13.