(4S)-4,5-dihydro-2-{2'-[(R)-1-(1-naphthyl)ethylamino]phenyl}-4-isopropyloxazole

Base Information

Chemical Name:(4S)-4,5-dihydro-2-{2'-[(R)-1-(1-naphthyl)ethylamino]phenyl}-4-isopropyloxazole
CAS No.:1340476-85-8
Molecular Formula:C₂₄H₂₆N₂O
Molecular Weight:358.483
Hs Code.:

Synonyms:(4S)-4,5-dihydro-2-{2'-[(R)-1-(1-naphthyl)ethylamino]phenyl}-4-isopropyloxazole

Suppliers and Price of (4S)-4,5-dihydro-2-{2'-[(R)-1-(1-naphthyl)ethylamino]phenyl}-4-isopropyloxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4S)-4,5-dihydro-2-{2'-[(R)-1-(1-naphthyl)ethylamino]phenyl}-4-isopropyloxazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4S)-4,5-dihydro-2-{2'-[(R)-1-(1-naphthyl)ethylamino]phenyl}-4-isopropyloxazole

There total 4 articles about (4S)-4,5-dihydro-2-{2'-[(R)-1-(1-naphthyl)ethylamino]phenyl}-4-isopropyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 3886-70-2
(R)-1-(1-Naphthyl)ethylamine

: 148836-24-2
(-)-(S)-2-(2-bromo-phenyl)-4-isopropyl-4,5-dihydro-oxazole

: 1340476-85-8
(4S)-4,5-dihydro-2-{2'-[(R)-1-(1-naphthyl)ethylamino]phenyl}-4-isopropyloxazole

Guidance literature:: With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 120 ℃; for 24h; Inert atmosphere;
DOI:10.1055/s-0030-1260124

Reference yield:

: 2026-48-4,473-75-6
(S)-valinol

: 1340476-85-8
(4S)-4,5-dihydro-2-{2'-[(R)-1-(1-naphthyl)ethylamino]phenyl}-4-isopropyloxazole

Guidance literature:: Multi-step reaction with 2 steps

1: zinc(II) chloride / chlorobenzene / 130 °C

2: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 24 h / 120 °C / Inert atmosphere

With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; zinc(II) chloride; sodium t-butanolate; In chlorobenzene; toluene; 2: Buchwald-Hartwig amination reaction;
DOI:10.1055/s-0030-1260124

Reference yield:

: 2042-37-7
o-cyanobromobenzene

: 1340476-85-8
(4S)-4,5-dihydro-2-{2'-[(R)-1-(1-naphthyl)ethylamino]phenyl}-4-isopropyloxazole

Guidance literature:: Multi-step reaction with 2 steps

1: zinc(II) chloride / chlorobenzene / 130 °C

2: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 24 h / 120 °C / Inert atmosphere

With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; zinc(II) chloride; sodium t-butanolate; In chlorobenzene; toluene; 2: Buchwald-Hartwig amination reaction;
DOI:10.1055/s-0030-1260124