148836-24-2

Basic information

• Product Name: (S)-2-(2-BROMOPHENYL)-4-ISOPROPYL-4,5-DIHYDROOXAZOLE
• Synonyms: (S)-2-(2-BROMOPHENYL)-4-ISOPROPYL-4,5-DIHYDROOXAZOLE;(4S)-2-(2-Bromophenyl)-4,5-dihydro-4-isopropyloxazole
• CAS NO: 148836-24-2
• Molecular Formula: C₁₂H₁₄BrNO
• Molecular Weight: 268.15
• Mol File: 148836-24-2.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-2-(2-BROMOPHENYL)-4-ISOPROPYL-4,5-DIHYDROOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(2-BROMOPHENYL)-4-ISOPROPYL-4,5-DIHYDROOXAZOLE(148836-24-2)
• EPA Substance Registry System: (S)-2-(2-BROMOPHENYL)-4-ISOPROPYL-4,5-DIHYDROOXAZOLE(148836-24-2)

Safety Data

• Hazardous Substances Data: 148836-24-2(Hazardous Substances Data)

Usage

Description

(S)-2-(2-BROMOPHENYL)-4-ISOPROPYL-4,5-DIHYDROOXAZOLE is a chiral oxazole derivative with the molecular formula C12H14BrNO. It features a bromophenyl and an isopropyl group attached to the oxazole ring, which may contribute to its potential applications in various fields.

Uses

Used in Pharmaceutical Research:
(S)-2-(2-BROMOPHENYL)-4-ISOPROPYL-4,5-DIHYDROOXAZOLE is used as a key intermediate in pharmaceutical research for the development of new drugs and pharmaceuticals. Its unique structure and chirality may offer advantages in the design and synthesis of novel therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, (S)-2-(2-BROMOPHENYL)-4-ISOPROPYL-4,5-DIHYDROOXAZOLE serves as a valuable building block for the creation of more complex molecules. Its bromophenyl and isopropyl substituents can be further functionalized or used as starting points for the synthesis of various organic compounds.

Upstream product

• 2026-48-4 (S)-valinol 
• 88-65-3 2-bromobenzoic-acid 
• 4001-73-4 2-Bromobenzamide 
• 7154-66-7 2-bromobenzoic acid chloride 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 154701-64-1 (4S)-4,5-dihydro-2-(2'-mercaptophenyl)-4-isopropyloxazole 
• 1340476-85-8 (4S)-4,5-dihydro-2-{2'-[(R)-1-(1-naphthyl)ethylamino]phenyl}-4-isopropyloxazole 
• 1340476-93-8 (4S)-4,5-dihydro-2-[2'-(2,6-diisopropylanilino)phenyl]-4-isopropyloxazole 
• 1340476-81-4 (4S)-4,5-dihydro-2-{2'-[(R)-α-methylbenzylamino]phenyl}-4-isopropyloxazole 
• 1340476-99-4 (4S)-4,5-dihydro-2-[2'-(benzamido)phenyl]-4-isopropyloxazole 
• 1340476-89-2 (4S)-4,5-dihydro-2-[2'-(2,6-dimethylanilino)phenyl]-4-isopropyloxazole 
• 1340477-03-3 (4S)-4,5-dihydro-2-{2'-[(S)-tert-butylsulfinamido]phenyl}-4-isopropyloxazole 
• 1374010-10-2 C₃₀H₃₃N₂O₃P 
• 148461-14-7 (4S)-2-[2-(diphenylphosphino)phenyl]-4-isopropyl-4,5-dihydro-1,3-oxazole 
• 180260-74-6 (S)-2-[2-(dicyclohexylphosphino)phenyl]-4-i-propyloxazoline 

Relevant articles and documents

Design of an Electron-Withdrawing Benzonitrile Ligand for Ni-Catalyzed Cross-Coupling Involving Tertiary Nucleophiles

The design of new ligands for cross-coupling is essential for developing new catalytic reactions that access valuable products such as pharmaceuticals. In this report, we exploit the reactivity of nitrile-containing additives in Ni catalysis to design a benzonitrile-containing ligand for cross-coupling involving tertiary nucleophiles. Kinetic and Hammett studies are used to elucidate the role of the optimized ligand, which demonstrate that the benzonitrile moiety acts as an electron-acceptor to promote reductive elimination over β-hydride elimination and stabilize low-valent Ni. With these conditions, a protocol for decyanation-metalation and Ni-catalyzed arylation is conducted, enabling access to quaternary α-arylnitriles from disubstituted malononitriles.

Preparation of Aryl(dicyclohexyl)phosphines by C-P Bond-Forming Cross-Coupling in Water Catalyzed by an Amphiphilic-Resin-Supported Palladium Complex

Aryl(dicyclohexyl)phosphines were prepared by a catalytic C-P bond-forming cross-coupling reaction of haloarenes with dicyclohexylphosphine under heterogeneous conditions in water containing an immobilized palladium complex coordinated to an amphiphilic polystyrene-poly(ethylene glycol) resin supported di(tert -butyl)phosphine ligand.

Ring-opening polymerization of rac-lactide with aluminum chiral anilido-oxazolinate complexes

A series of dimethylaluminum complexes (L1a-i)AlMe2 (2a-i, where HL1a-i = 2-(2′-ArNH)phenyl-4-R1- oxazoline) bearing chiral, bidentate anilido-oxazolinate ligands have been prepared and characterized. Six of the